The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

LncRNAs influence endothelial cell function via a number of mechanisms. Here the authors show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-mesenchymal transition and angiogenesis.

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Autores principales:	Philipp Neumann, Nicolas Jaé, Andrea Knau, Simone F. Glaser, Youssef Fouani, Oliver Rossbach, Marcus Krüger, David John, Albrecht Bindereif, Phillip Grote, Reinier A. Boon, Stefanie Dimmeler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e25bac665132408db6264774e60c5b11
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spelling	oai:doaj.org-article:e25bac665132408db6264774e60c5b112021-12-02T17:33:06ZThe lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL210.1038/s41467-017-02431-12041-1723https://doaj.org/article/e25bac665132408db6264774e60c5b112018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02431-1https://doaj.org/toc/2041-1723LncRNAs influence endothelial cell function via a number of mechanisms. Here the authors show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-mesenchymal transition and angiogenesis.Philipp NeumannNicolas JaéAndrea KnauSimone F. GlaserYoussef FouaniOliver RossbachMarcus KrügerDavid JohnAlbrecht BindereifPhillip GroteReinier A. BoonStefanie DimmelerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philipp Neumann Nicolas Jaé Andrea Knau Simone F. Glaser Youssef Fouani Oliver Rossbach Marcus Krüger David John Albrecht Bindereif Phillip Grote Reinier A. Boon Stefanie Dimmeler The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2
description	LncRNAs influence endothelial cell function via a number of mechanisms. Here the authors show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-mesenchymal transition and angiogenesis.
format	article
author	Philipp Neumann Nicolas Jaé Andrea Knau Simone F. Glaser Youssef Fouani Oliver Rossbach Marcus Krüger David John Albrecht Bindereif Phillip Grote Reinier A. Boon Stefanie Dimmeler
author_facet	Philipp Neumann Nicolas Jaé Andrea Knau Simone F. Glaser Youssef Fouani Oliver Rossbach Marcus Krüger David John Albrecht Bindereif Phillip Grote Reinier A. Boon Stefanie Dimmeler
author_sort	Philipp Neumann
title	The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2
title_short	The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2
title_full	The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2
title_fullStr	The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2
title_full_unstemmed	The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2
title_sort	lncrna gata6-as epigenetically regulates endothelial gene expression via interaction with loxl2
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e25bac665132408db6264774e60c5b11
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The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

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