A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calor...
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2008
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oai:doaj.org-article:e25f222114b3420ba995866183387c342021-11-25T06:12:12ZA low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.1932-620310.1371/journal.pone.0002264https://doaj.org/article/e25f222114b3420ba995866183387c342008-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18523577/?tool=EBIhttps://doaj.org/toc/1932-6203Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.Jamie L BargerTsuyoshi KayoJames M VannEdward B AriasJelai WangTimothy A HackerYing WangDaniel RaederstorffJason D MorrowChristiaan LeeuwenburghDavid B AllisonKurt W SaupeGregory D CarteeRichard WeindruchTomas A ProllaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 6, p e2264 (2008) |
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Medicine R Science Q |
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Medicine R Science Q Jamie L Barger Tsuyoshi Kayo James M Vann Edward B Arias Jelai Wang Timothy A Hacker Ying Wang Daniel Raederstorff Jason D Morrow Christiaan Leeuwenburgh David B Allison Kurt W Saupe Gregory D Cartee Richard Weindruch Tomas A Prolla A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. |
| description |
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR. |
| format |
article |
| author |
Jamie L Barger Tsuyoshi Kayo James M Vann Edward B Arias Jelai Wang Timothy A Hacker Ying Wang Daniel Raederstorff Jason D Morrow Christiaan Leeuwenburgh David B Allison Kurt W Saupe Gregory D Cartee Richard Weindruch Tomas A Prolla |
| author_facet |
Jamie L Barger Tsuyoshi Kayo James M Vann Edward B Arias Jelai Wang Timothy A Hacker Ying Wang Daniel Raederstorff Jason D Morrow Christiaan Leeuwenburgh David B Allison Kurt W Saupe Gregory D Cartee Richard Weindruch Tomas A Prolla |
| author_sort |
Jamie L Barger |
| title |
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. |
| title_short |
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. |
| title_full |
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. |
| title_fullStr |
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. |
| title_full_unstemmed |
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. |
| title_sort |
low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2008 |
| url |
https://doaj.org/article/e25f222114b3420ba995866183387c34 |
| work_keys_str_mv |
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