A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases

Abstract Inosine-5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using t...

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Autores principales: Rubén M. Buey, David Fernández-Justel, Íñigo Marcos-Alcalde, Graeme Winter, Paulino Gómez-Puertas, José María de Pereda, José Luis Revuelta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e25f495f01384a6dbd80c2e6b87dba31
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