MELT GRANULATION IN HIGH SHEAR MIXER

Melt granulation in a high-shear mixer is an alternative technique that converts fine powders into granules. The powder agglomeration is promoted by the addition of a low melting point binder, which is solid at room temperature and melts at relatively low temperatures (50-80 ºC). This technique i...

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Autores principales:	Lourdes OCHOA D., Manuela IGARTUA O., Rosa M. HERNÁNDEZ M., Alicia R. GASCÓN, José L. PEDRAZ M.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Melt granulation high shear mixer binder. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/e2602d336c404a2a876a5563e385e7d5
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id	oai:doaj.org-article:e2602d336c404a2a876a5563e385e7d5
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spelling	oai:doaj.org-article:e2602d336c404a2a876a5563e385e7d52021-11-19T04:22:34ZMELT GRANULATION IN HIGH SHEAR MIXER0121-40042145-2660https://doaj.org/article/e2602d336c404a2a876a5563e385e7d52009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/524https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Melt granulation in a high-shear mixer is an alternative technique that converts fine powders into granules. The powder agglomeration is promoted by the addition of a low melting point binder, which is solid at room temperature and melts at relatively low temperatures (50-80 ºC). This technique is a good alternative to the conventional wet granulation process when the use of solvents is not indicated. Moreover, it offers several advantages since the drying phase is eliminated and the process is less consuming in terms of time and energy. By selecting the suitable binder, melt granulation can be used either to prepare immediate or controlled release formulations. One of the equipments most commonly used for melt granulation is the high shear mixer, which allows to development the process in “one-step”. Additionally, when the process is optimized, it makes possible the industrial scaling-up. This paper focuses on the description of the melt granulation technique and the parameters that influence the process in high shear mixers. Lourdes OCHOA D.Manuela IGARTUA O.Rosa M. HERNÁNDEZ M.Alicia R. GASCÓNJosé L. PEDRAZ M.Universidad de AntioquiaarticleMelt granulationhigh shear mixerbinder.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 13, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Melt granulation high shear mixer binder. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Melt granulation high shear mixer binder. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Lourdes OCHOA D. Manuela IGARTUA O. Rosa M. HERNÁNDEZ M. Alicia R. GASCÓN José L. PEDRAZ M. MELT GRANULATION IN HIGH SHEAR MIXER
description	Melt granulation in a high-shear mixer is an alternative technique that converts fine powders into granules. The powder agglomeration is promoted by the addition of a low melting point binder, which is solid at room temperature and melts at relatively low temperatures (50-80 ºC). This technique is a good alternative to the conventional wet granulation process when the use of solvents is not indicated. Moreover, it offers several advantages since the drying phase is eliminated and the process is less consuming in terms of time and energy. By selecting the suitable binder, melt granulation can be used either to prepare immediate or controlled release formulations. One of the equipments most commonly used for melt granulation is the high shear mixer, which allows to development the process in “one-step”. Additionally, when the process is optimized, it makes possible the industrial scaling-up. This paper focuses on the description of the melt granulation technique and the parameters that influence the process in high shear mixers.
format	article
author	Lourdes OCHOA D. Manuela IGARTUA O. Rosa M. HERNÁNDEZ M. Alicia R. GASCÓN José L. PEDRAZ M.
author_facet	Lourdes OCHOA D. Manuela IGARTUA O. Rosa M. HERNÁNDEZ M. Alicia R. GASCÓN José L. PEDRAZ M.
author_sort	Lourdes OCHOA D.
title	MELT GRANULATION IN HIGH SHEAR MIXER
title_short	MELT GRANULATION IN HIGH SHEAR MIXER
title_full	MELT GRANULATION IN HIGH SHEAR MIXER
title_fullStr	MELT GRANULATION IN HIGH SHEAR MIXER
title_full_unstemmed	MELT GRANULATION IN HIGH SHEAR MIXER
title_sort	melt granulation in high shear mixer
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/e2602d336c404a2a876a5563e385e7d5
work_keys_str_mv	AT lourdesochoad meltgranulationinhighshearmixer AT manuelaigartuao meltgranulationinhighshearmixer AT rosamhernandezm meltgranulationinhighshearmixer AT aliciargascon meltgranulationinhighshearmixer AT joselpedrazm meltgranulationinhighshearmixer
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MELT GRANULATION IN HIGH SHEAR MIXER

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