Mirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy

Alexandre Cesar Vieira Sales,1,2 Isaura Isabelle Fonseca Gomes da Silva,1 Matheus CB Leite,1 Leandro L Coutinho,1 Renata BAC Reis,1 Angela Castoldi,1 Danyelly BG Martins,1 José Luiz Lima-Filho,1 Fabricio Oliveira Souto1,2 1Keizo Asami Immunopathology Laboratory, LIKA/Federal University of...

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Autores principales:	Sales ACV, Gomes da Silva IIF, Leite MCB, Coutinho LL, Reis RBAC, Castoldi A, B. G. Martins D, Lima-Filho JL, Souto FO
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	mirna-21 breast cancer biomarker tumor tissue neoadjuvant chemotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e266c97271074a548d72c5d02ef8f49b
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spelling	oai:doaj.org-article:e266c97271074a548d72c5d02ef8f49b2021-12-02T10:18:25ZMirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy1179-1314https://doaj.org/article/e266c97271074a548d72c5d02ef8f49b2020-10-01T00:00:00Zhttps://www.dovepress.com/mirna21-expression-in-the-breast-cancer-tumor-tissue-is-independent-of-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Alexandre Cesar Vieira Sales,1,2 Isaura Isabelle Fonseca Gomes da Silva,1 Matheus CB Leite,1 Leandro L Coutinho,1 Renata BAC Reis,1 Angela Castoldi,1 Danyelly BG Martins,1 José Luiz Lima-Filho,1 Fabricio Oliveira Souto1,2 1Keizo Asami Immunopathology Laboratory, LIKA/Federal University of Pernambuco – UFPE, Recife, PE, Brazil; 2Life Sciences Nucleus– NCV, Agreste Academic Center– CAA, Federal University of Pernambuco – UFPE, Caruaru, PE, BrazilCorrespondence: Alexandre Cesar Vieira Sales; Fabricio Oliveira SoutoKeizo Asami Immunopathology Laboratory, LIKA/Federal University of Pernambuco – UFPE, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE 52171-011, Brazil+55 (81) 2126-8484; +55 (81) 2126-8484Email ac.sales@uol.com.br; fabricio.souto@ufpe.brIntroduction: MicroRNA-21 (miRNA-21) has been described as one of the most significantly upregulated miRNAs in human breast cancer. However, limited knowledge exists on miRNA-21 expression in breast cancer tissue after neoadjuvant chemotherapy (NAC).Purpose: The aim of this study was to assess miRNA-21 expression in the tumor tissues of Brazilian patients with breast cancer who underwent NAC and its correlation with clinicopathological variables.Patients and Methods: Utilizing qRT-PCR, miRNA-21 expression in tumor tissue was measured in a cohort of female patients with breast cancer who underwent NAC. The correlation of miRNA-21 expression with breast cancer molecular subtypes and other clinicopathological variables was also assessed.Results: A total of 55 patients were included in the study, and 28 (50.9%) underwent NAC. miRNA-21 was upregulated in patients with breast cancer, regardless of previous exposure to chemotherapy, molecular subtypes, tumor-node-metastasis (TNM) staging and lymph node status of the axilla. miRNA-21 expression did not differ between patients with breast cancer who achieved a pathologic complete response after NAC and healthy controls.Conclusion: miRNA-21 was upregulated in the tumor tissue of Brazilian patients with breast cancer regardless of NAC treatment, which reinforces its role as an “oncomiR” and a potential biomarker.Keywords: miRNA-21, breast cancer, biomarker, tumor tissue, neoadjuvant chemotherapySales ACVGomes da Silva IIFLeite MCBCoutinho LLReis RBACCastoldi AB. G. Martins DLima-Filho JLSouto FODove Medical Pressarticlemirna-21breast cancerbiomarkertumor tissueneoadjuvant chemotherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 12, Pp 141-151 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	mirna-21 breast cancer biomarker tumor tissue neoadjuvant chemotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	mirna-21 breast cancer biomarker tumor tissue neoadjuvant chemotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sales ACV Gomes da Silva IIF Leite MCB Coutinho LL Reis RBAC Castoldi A B. G. Martins D Lima-Filho JL Souto FO Mirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy
description	Alexandre Cesar Vieira Sales,1,2 Isaura Isabelle Fonseca Gomes da Silva,1 Matheus CB Leite,1 Leandro L Coutinho,1 Renata BAC Reis,1 Angela Castoldi,1 Danyelly BG Martins,1 José Luiz Lima-Filho,1 Fabricio Oliveira Souto1,2 1Keizo Asami Immunopathology Laboratory, LIKA/Federal University of Pernambuco – UFPE, Recife, PE, Brazil; 2Life Sciences Nucleus– NCV, Agreste Academic Center– CAA, Federal University of Pernambuco – UFPE, Caruaru, PE, BrazilCorrespondence: Alexandre Cesar Vieira Sales; Fabricio Oliveira SoutoKeizo Asami Immunopathology Laboratory, LIKA/Federal University of Pernambuco – UFPE, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE 52171-011, Brazil+55 (81) 2126-8484; +55 (81) 2126-8484Email ac.sales@uol.com.br; fabricio.souto@ufpe.brIntroduction: MicroRNA-21 (miRNA-21) has been described as one of the most significantly upregulated miRNAs in human breast cancer. However, limited knowledge exists on miRNA-21 expression in breast cancer tissue after neoadjuvant chemotherapy (NAC).Purpose: The aim of this study was to assess miRNA-21 expression in the tumor tissues of Brazilian patients with breast cancer who underwent NAC and its correlation with clinicopathological variables.Patients and Methods: Utilizing qRT-PCR, miRNA-21 expression in tumor tissue was measured in a cohort of female patients with breast cancer who underwent NAC. The correlation of miRNA-21 expression with breast cancer molecular subtypes and other clinicopathological variables was also assessed.Results: A total of 55 patients were included in the study, and 28 (50.9%) underwent NAC. miRNA-21 was upregulated in patients with breast cancer, regardless of previous exposure to chemotherapy, molecular subtypes, tumor-node-metastasis (TNM) staging and lymph node status of the axilla. miRNA-21 expression did not differ between patients with breast cancer who achieved a pathologic complete response after NAC and healthy controls.Conclusion: miRNA-21 was upregulated in the tumor tissue of Brazilian patients with breast cancer regardless of NAC treatment, which reinforces its role as an “oncomiR” and a potential biomarker.Keywords: miRNA-21, breast cancer, biomarker, tumor tissue, neoadjuvant chemotherapy
format	article
author	Sales ACV Gomes da Silva IIF Leite MCB Coutinho LL Reis RBAC Castoldi A B. G. Martins D Lima-Filho JL Souto FO
author_facet	Sales ACV Gomes da Silva IIF Leite MCB Coutinho LL Reis RBAC Castoldi A B. G. Martins D Lima-Filho JL Souto FO
author_sort	Sales ACV
title	Mirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy
title_short	Mirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy
title_full	Mirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy
title_fullStr	Mirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy
title_full_unstemmed	Mirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy
title_sort	mirna21 expression in the breast cancer tumor tissue is independent of neoadjuvant chemotherapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e266c97271074a548d72c5d02ef8f49b
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Mirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy

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