Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy

Tumor oxygenation level has been regarded as an attractive target to elevate the efficiency of photodynamic therapy (PDT). Cyanobacterial photosynthesis-mediated reversal of tumor hypoxia could enable an oxygen-boosted PDT, but is limited by scant penetration depth and efficiency of external light....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Meiqi Chang, Wei Feng, Li Ding, Hongguang Zhang, Caihong Dong, Yu Chen, Jianlin Shi
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Photodynamic therapy Cyanobacteria Persistent luminescence Oxygenation Irradiation-free Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e2681b8f0b054f58bb5e5de0105f3225
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e2681b8f0b054f58bb5e5de0105f3225
record_format	dspace
spelling	oai:doaj.org-article:e2681b8f0b054f58bb5e5de0105f32252021-11-26T04:36:59ZPersistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy2452-199X10.1016/j.bioactmat.2021.08.030https://doaj.org/article/e2681b8f0b054f58bb5e5de0105f32252022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21004060https://doaj.org/toc/2452-199XTumor oxygenation level has been regarded as an attractive target to elevate the efficiency of photodynamic therapy (PDT). Cyanobacterial photosynthesis-mediated reversal of tumor hypoxia could enable an oxygen-boosted PDT, but is limited by scant penetration depth and efficiency of external light. Herein, aiming at the dual purposes of reducing biological toxicity induced by long-term light irradiation and alleviating hypoxia, we here introduce a novel-designed CaAl2O4:Eu,Nd blue persistent luminescence material (PLM) as the in vivo light source after pre-excited in vitro. The ingenious construction of blue-emitting PLM with “optical battery” characteristics activates cyanobacterial cells and verteporfin simultaneously, which performs the successive oxygen supply and singlet oxygen generation without the long-term external excitation, resulting in the modulated tumor hypoxic microenvironment and enhanced photodynamic tumor proliferation inhibition efficiency. Both in vitro cellular assessment and in vivo tumor evaluation results affirm the advantages of self-produced oxygen PDT system and evidence the notable antineoplastic outcome. This work develops an irradiation-free photosynthetic bacteria-based PDT platform for the optimization of both oxygen production capacity and light utilization efficiency in cancer treatment, which is expected to promote the clinical progress of microbial-based photonic therapy.Meiqi ChangWei FengLi DingHongguang ZhangCaihong DongYu ChenJianlin ShiKeAi Communications Co., Ltd.articlePhotodynamic therapyCyanobacteriaPersistent luminescenceOxygenationIrradiation-freeMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 131-144 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Photodynamic therapy Cyanobacteria Persistent luminescence Oxygenation Irradiation-free Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Photodynamic therapy Cyanobacteria Persistent luminescence Oxygenation Irradiation-free Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Meiqi Chang Wei Feng Li Ding Hongguang Zhang Caihong Dong Yu Chen Jianlin Shi Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy
description	Tumor oxygenation level has been regarded as an attractive target to elevate the efficiency of photodynamic therapy (PDT). Cyanobacterial photosynthesis-mediated reversal of tumor hypoxia could enable an oxygen-boosted PDT, but is limited by scant penetration depth and efficiency of external light. Herein, aiming at the dual purposes of reducing biological toxicity induced by long-term light irradiation and alleviating hypoxia, we here introduce a novel-designed CaAl2O4:Eu,Nd blue persistent luminescence material (PLM) as the in vivo light source after pre-excited in vitro. The ingenious construction of blue-emitting PLM with “optical battery” characteristics activates cyanobacterial cells and verteporfin simultaneously, which performs the successive oxygen supply and singlet oxygen generation without the long-term external excitation, resulting in the modulated tumor hypoxic microenvironment and enhanced photodynamic tumor proliferation inhibition efficiency. Both in vitro cellular assessment and in vivo tumor evaluation results affirm the advantages of self-produced oxygen PDT system and evidence the notable antineoplastic outcome. This work develops an irradiation-free photosynthetic bacteria-based PDT platform for the optimization of both oxygen production capacity and light utilization efficiency in cancer treatment, which is expected to promote the clinical progress of microbial-based photonic therapy.
format	article
author	Meiqi Chang Wei Feng Li Ding Hongguang Zhang Caihong Dong Yu Chen Jianlin Shi
author_facet	Meiqi Chang Wei Feng Li Ding Hongguang Zhang Caihong Dong Yu Chen Jianlin Shi
author_sort	Meiqi Chang
title	Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy
title_short	Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy
title_full	Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy
title_fullStr	Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy
title_full_unstemmed	Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy
title_sort	persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/e2681b8f0b054f58bb5e5de0105f3225
work_keys_str_mv	AT meiqichang persistentluminescencephosphorasinvivolightsourcefortumoralcyanobacterialphotosyntheticoxygenationandphotodynamictherapy AT weifeng persistentluminescencephosphorasinvivolightsourcefortumoralcyanobacterialphotosyntheticoxygenationandphotodynamictherapy AT liding persistentluminescencephosphorasinvivolightsourcefortumoralcyanobacterialphotosyntheticoxygenationandphotodynamictherapy AT hongguangzhang persistentluminescencephosphorasinvivolightsourcefortumoralcyanobacterialphotosyntheticoxygenationandphotodynamictherapy AT caihongdong persistentluminescencephosphorasinvivolightsourcefortumoralcyanobacterialphotosyntheticoxygenationandphotodynamictherapy AT yuchen persistentluminescencephosphorasinvivolightsourcefortumoralcyanobacterialphotosyntheticoxygenationandphotodynamictherapy AT jianlinshi persistentluminescencephosphorasinvivolightsourcefortumoralcyanobacterialphotosyntheticoxygenationandphotodynamictherapy
_version_	1718409873548378112

Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy

Ejemplares similares