Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging

Abstract Standard clinical X-ray contrast agents are small iodine-containing molecules that are rapidly cleared by the kidneys and provide robust imaging for only a few seconds, thereby limiting more extensive vascular and tissue biodistribution imaging as well as optimal tumor uptake. They are also...

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Autores principales:	James F. Hainfeld, Sharif M. Ridwan, Yaroslav Stanishevskiy, Nathaniel R. Smilowitz, James Davis, Henry M. Smilowitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Longer Blood Half-life microCT Images Tumour Load Liver Clearance High Resolution Image Acquisition Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e2691781666a4a66a77ed31f2d8a63c7
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spelling	oai:doaj.org-article:e2691781666a4a66a77ed31f2d8a63c72021-12-02T15:05:41ZSmall, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging10.1038/s41598-018-31940-22045-2322https://doaj.org/article/e2691781666a4a66a77ed31f2d8a63c72018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31940-2https://doaj.org/toc/2045-2322Abstract Standard clinical X-ray contrast agents are small iodine-containing molecules that are rapidly cleared by the kidneys and provide robust imaging for only a few seconds, thereby limiting more extensive vascular and tissue biodistribution imaging as well as optimal tumor uptake. They are also not generally useful for preclinical microCT imaging where longer scan times are required for high resolution image acquisition. We here describe a new iodine nanoparticle contrast agent that has a unique combination of properties: 20 nm hydrodynamic diameter, covalent PEG coating, 40 hour blood half-life, 50% liver clearance after six months, accumulation in tumors, and well-tolerated to at least 4 g iodine/kg body weight after intravenous administration in mice. These characteristics are unique among the other iodine nanoparticles that have been previously reported and provide extended-time high contrast vascular imaging and tumor loading. As such, it is useful for preclinical MicroCT animal studies. Potential human applications might include X-ray radiation dose enhancement for cancer therapy and vascular imaging for life-threatening situations where high levels of contrast are needed for extended periods of time.James F. HainfeldSharif M. RidwanYaroslav StanishevskiyNathaniel R. SmilowitzJames DavisHenry M. SmilowitzNature PortfolioarticleLonger Blood Half-lifemicroCT ImagesTumour LoadLiver ClearanceHigh Resolution Image AcquisitionMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Longer Blood Half-life microCT Images Tumour Load Liver Clearance High Resolution Image Acquisition Medicine R Science Q
spellingShingle	Longer Blood Half-life microCT Images Tumour Load Liver Clearance High Resolution Image Acquisition Medicine R Science Q James F. Hainfeld Sharif M. Ridwan Yaroslav Stanishevskiy Nathaniel R. Smilowitz James Davis Henry M. Smilowitz Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging
description	Abstract Standard clinical X-ray contrast agents are small iodine-containing molecules that are rapidly cleared by the kidneys and provide robust imaging for only a few seconds, thereby limiting more extensive vascular and tissue biodistribution imaging as well as optimal tumor uptake. They are also not generally useful for preclinical microCT imaging where longer scan times are required for high resolution image acquisition. We here describe a new iodine nanoparticle contrast agent that has a unique combination of properties: 20 nm hydrodynamic diameter, covalent PEG coating, 40 hour blood half-life, 50% liver clearance after six months, accumulation in tumors, and well-tolerated to at least 4 g iodine/kg body weight after intravenous administration in mice. These characteristics are unique among the other iodine nanoparticles that have been previously reported and provide extended-time high contrast vascular imaging and tumor loading. As such, it is useful for preclinical MicroCT animal studies. Potential human applications might include X-ray radiation dose enhancement for cancer therapy and vascular imaging for life-threatening situations where high levels of contrast are needed for extended periods of time.
format	article
author	James F. Hainfeld Sharif M. Ridwan Yaroslav Stanishevskiy Nathaniel R. Smilowitz James Davis Henry M. Smilowitz
author_facet	James F. Hainfeld Sharif M. Ridwan Yaroslav Stanishevskiy Nathaniel R. Smilowitz James Davis Henry M. Smilowitz
author_sort	James F. Hainfeld
title	Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging
title_short	Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging
title_full	Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging
title_fullStr	Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging
title_full_unstemmed	Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging
title_sort	small, long blood half-life iodine nanoparticle for vascular and tumor imaging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e2691781666a4a66a77ed31f2d8a63c7
work_keys_str_mv	AT jamesfhainfeld smalllongbloodhalflifeiodinenanoparticleforvascularandtumorimaging AT sharifmridwan smalllongbloodhalflifeiodinenanoparticleforvascularandtumorimaging AT yaroslavstanishevskiy smalllongbloodhalflifeiodinenanoparticleforvascularandtumorimaging AT nathanielrsmilowitz smalllongbloodhalflifeiodinenanoparticleforvascularandtumorimaging AT jamesdavis smalllongbloodhalflifeiodinenanoparticleforvascularandtumorimaging AT henrymsmilowitz smalllongbloodhalflifeiodinenanoparticleforvascularandtumorimaging
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Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging

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