Severe obesity in young women and reproductive health: the Danish National Birth Cohort.

<h4>Background</h4>Little is known about reproductive health in severely obese women. In this study, we present associations between different levels of severe obesity and a wide range of health outcomes in the mother and child.<h4>Methods</h4>From the Danish National Birth C...

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Autores principales:	Ellen A Nohr, Nicholas J Timpson, Camilla S Andersen, George Davey Smith, Jørn Olsen, Thorkild I A Sørensen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e26b3573414441af9594faa2264c5306
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spelling	oai:doaj.org-article:e26b3573414441af9594faa2264c53062021-11-25T06:27:07ZSevere obesity in young women and reproductive health: the Danish National Birth Cohort.1932-620310.1371/journal.pone.0008444https://doaj.org/article/e26b3573414441af9594faa2264c53062009-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20041193/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Little is known about reproductive health in severely obese women. In this study, we present associations between different levels of severe obesity and a wide range of health outcomes in the mother and child.<h4>Methods</h4>From the Danish National Birth Cohort, we obtained self-reported information about prepregnant body mass index (BMI) for 2451 severely obese women and 2450 randomly selected women from the remaining cohort who served as a comparison group. Information about maternal and infant outcomes was also self-reported or came from registers. Logistic regression was used to estimate the association between different levels of severe obesity and reproductive outcomes.<h4>Principal findings</h4>Subfecundity was more frequent in severely obese women, and during pregnancy, they had an excess risk of urinary tract infections, gestational diabetes, preeclampsia and other hypertensive disorders which increased with severity of obesity. They tended to have a higher risk of both pre- and post-term birth, and risk of cesarean and instrumental deliveries increased across obesity categories. After birth, severely obese women more often failed to initiate or sustain breastfeeding. Risk of weight retention 1.5 years after birth was similar to that of other women, but after adjustment for gestational weight gain, the risk was increased, especially in women in the lowest obesity category. In infants, increasing maternal obesity was associated with decreased risk of a low birth weight and increased risk of a high birth weight. Estimates for ponderal index showed the same pattern indicating an increasing risk of neonatal fatness with severity of obesity. Infant obesity measured one year after birth was also increased in children of severely obese mothers.<h4>Conclusion</h4>Severe obesity is correlated with a substantial disease burden in reproductive health. Although the causal mechanisms remain elusive, these findings are useful for making predictions and planning health care at the individual level.Ellen A NohrNicholas J TimpsonCamilla S AndersenGeorge Davey SmithJørn OlsenThorkild I A SørensenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 12, p e8444 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ellen A Nohr Nicholas J Timpson Camilla S Andersen George Davey Smith Jørn Olsen Thorkild I A Sørensen Severe obesity in young women and reproductive health: the Danish National Birth Cohort.
description	<h4>Background</h4>Little is known about reproductive health in severely obese women. In this study, we present associations between different levels of severe obesity and a wide range of health outcomes in the mother and child.<h4>Methods</h4>From the Danish National Birth Cohort, we obtained self-reported information about prepregnant body mass index (BMI) for 2451 severely obese women and 2450 randomly selected women from the remaining cohort who served as a comparison group. Information about maternal and infant outcomes was also self-reported or came from registers. Logistic regression was used to estimate the association between different levels of severe obesity and reproductive outcomes.<h4>Principal findings</h4>Subfecundity was more frequent in severely obese women, and during pregnancy, they had an excess risk of urinary tract infections, gestational diabetes, preeclampsia and other hypertensive disorders which increased with severity of obesity. They tended to have a higher risk of both pre- and post-term birth, and risk of cesarean and instrumental deliveries increased across obesity categories. After birth, severely obese women more often failed to initiate or sustain breastfeeding. Risk of weight retention 1.5 years after birth was similar to that of other women, but after adjustment for gestational weight gain, the risk was increased, especially in women in the lowest obesity category. In infants, increasing maternal obesity was associated with decreased risk of a low birth weight and increased risk of a high birth weight. Estimates for ponderal index showed the same pattern indicating an increasing risk of neonatal fatness with severity of obesity. Infant obesity measured one year after birth was also increased in children of severely obese mothers.<h4>Conclusion</h4>Severe obesity is correlated with a substantial disease burden in reproductive health. Although the causal mechanisms remain elusive, these findings are useful for making predictions and planning health care at the individual level.
format	article
author	Ellen A Nohr Nicholas J Timpson Camilla S Andersen George Davey Smith Jørn Olsen Thorkild I A Sørensen
author_facet	Ellen A Nohr Nicholas J Timpson Camilla S Andersen George Davey Smith Jørn Olsen Thorkild I A Sørensen
author_sort	Ellen A Nohr
title	Severe obesity in young women and reproductive health: the Danish National Birth Cohort.
title_short	Severe obesity in young women and reproductive health: the Danish National Birth Cohort.
title_full	Severe obesity in young women and reproductive health: the Danish National Birth Cohort.
title_fullStr	Severe obesity in young women and reproductive health: the Danish National Birth Cohort.
title_full_unstemmed	Severe obesity in young women and reproductive health: the Danish National Birth Cohort.
title_sort	severe obesity in young women and reproductive health: the danish national birth cohort.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/e26b3573414441af9594faa2264c5306
work_keys_str_mv	AT ellenanohr severeobesityinyoungwomenandreproductivehealththedanishnationalbirthcohort AT nicholasjtimpson severeobesityinyoungwomenandreproductivehealththedanishnationalbirthcohort AT camillasandersen severeobesityinyoungwomenandreproductivehealththedanishnationalbirthcohort AT georgedaveysmith severeobesityinyoungwomenandreproductivehealththedanishnationalbirthcohort AT jørnolsen severeobesityinyoungwomenandreproductivehealththedanishnationalbirthcohort AT thorkildiasørensen severeobesityinyoungwomenandreproductivehealththedanishnationalbirthcohort
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Severe obesity in young women and reproductive health: the Danish National Birth Cohort.

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