Quantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis

Abstract [18F]9-fluoropropyl-(+)-dihydrotetrabenazine (18F-(+)DTBZ) is a recently developed PET tracer to investigate the vesicular monoamine transporter type 2 (VMAT2) activity in measuring dopaminergic degeneration in vivo and monitoring the severity of Parkinson’s disease (PD). However, manual dr...

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Autores principales:	Hsu Jung Lung, Yi-Hsin Weng, Ming-Ching Wen, Ing-Tsung Hsiao, Kun-Ju Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Specific Uptake Ratio (SURs) Vesicular Monoamine Transporter Type 2 (VMAT2) Putaminal Region Posterior Putamina Early Phase Images Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e270606fcffc40d1ab4a338acefae247
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spelling	oai:doaj.org-article:e270606fcffc40d1ab4a338acefae2472021-12-02T15:08:27ZQuantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis10.1038/s41598-018-34388-62045-2322https://doaj.org/article/e270606fcffc40d1ab4a338acefae2472018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34388-6https://doaj.org/toc/2045-2322Abstract [18F]9-fluoropropyl-(+)-dihydrotetrabenazine (18F-(+)DTBZ) is a recently developed PET tracer to investigate the vesicular monoamine transporter type 2 (VMAT2) activity in measuring dopaminergic degeneration in vivo and monitoring the severity of Parkinson’s disease (PD). However, manual drawing of the striatal regions is time consuming and prone to human bias. In the current study, we developed an automated method to quantify the signals of the striatum on 18F-(+)DTBZ images. 39 patients with PD and 26 controls were enrolled. Traditional brain magnetic resonance imaging (MRI) and 18F-(+)DTBZ PET were acquired. Both indirect normalization of native PET images to the standard space through individual brain MRI and directly coregistration of native images to the transporter-specific PET template in standard space were performed. Specific uptake ratios (SURs) in 10 predefined regions were used as indicators of VMAT2 activities to correlate with motor severity. Our results showed patients with PD had significant lower SURs in the bilateral putamina, caudates and globus pallidi than controls. SURs in the caudate and putamen were significantly correlated with motor severity. The contralateral putaminal region performed best in discriminating between PD patients and controls. Finally, the results from the application of the 18F-(+)DTBZ PET template were comparable to those derived from the traditional MRI based method. Thus, 18F-(+)DTBZ PET imaging holds the potential to effectively differentiate PD patients from controls. The 18F-(+)DTBZ PET template-based method for automated quantification of presynaptic VMAT2 transporter density is easier to implement and may facilitate efficient, robust and user-independent image analysis.Hsu Jung LungYi-Hsin WengMing-Ching WenIng-Tsung HsiaoKun-Ju LinNature PortfolioarticleSpecific Uptake Ratio (SURs)Vesicular Monoamine Transporter Type 2 (VMAT2)Putaminal RegionPosterior PutaminaEarly Phase ImagesMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specific Uptake Ratio (SURs) Vesicular Monoamine Transporter Type 2 (VMAT2) Putaminal Region Posterior Putamina Early Phase Images Medicine R Science Q
spellingShingle	Specific Uptake Ratio (SURs) Vesicular Monoamine Transporter Type 2 (VMAT2) Putaminal Region Posterior Putamina Early Phase Images Medicine R Science Q Hsu Jung Lung Yi-Hsin Weng Ming-Ching Wen Ing-Tsung Hsiao Kun-Ju Lin Quantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis
description	Abstract [18F]9-fluoropropyl-(+)-dihydrotetrabenazine (18F-(+)DTBZ) is a recently developed PET tracer to investigate the vesicular monoamine transporter type 2 (VMAT2) activity in measuring dopaminergic degeneration in vivo and monitoring the severity of Parkinson’s disease (PD). However, manual drawing of the striatal regions is time consuming and prone to human bias. In the current study, we developed an automated method to quantify the signals of the striatum on 18F-(+)DTBZ images. 39 patients with PD and 26 controls were enrolled. Traditional brain magnetic resonance imaging (MRI) and 18F-(+)DTBZ PET were acquired. Both indirect normalization of native PET images to the standard space through individual brain MRI and directly coregistration of native images to the transporter-specific PET template in standard space were performed. Specific uptake ratios (SURs) in 10 predefined regions were used as indicators of VMAT2 activities to correlate with motor severity. Our results showed patients with PD had significant lower SURs in the bilateral putamina, caudates and globus pallidi than controls. SURs in the caudate and putamen were significantly correlated with motor severity. The contralateral putaminal region performed best in discriminating between PD patients and controls. Finally, the results from the application of the 18F-(+)DTBZ PET template were comparable to those derived from the traditional MRI based method. Thus, 18F-(+)DTBZ PET imaging holds the potential to effectively differentiate PD patients from controls. The 18F-(+)DTBZ PET template-based method for automated quantification of presynaptic VMAT2 transporter density is easier to implement and may facilitate efficient, robust and user-independent image analysis.
format	article
author	Hsu Jung Lung Yi-Hsin Weng Ming-Ching Wen Ing-Tsung Hsiao Kun-Ju Lin
author_facet	Hsu Jung Lung Yi-Hsin Weng Ming-Ching Wen Ing-Tsung Hsiao Kun-Ju Lin
author_sort	Hsu Jung Lung
title	Quantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis
title_short	Quantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis
title_full	Quantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis
title_fullStr	Quantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis
title_full_unstemmed	Quantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis
title_sort	quantitative study of 18f-(+)dtbz image: comparison of pet template-based and mri based image analysis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e270606fcffc40d1ab4a338acefae247
work_keys_str_mv	AT hsujunglung quantitativestudyof18fdtbzimagecomparisonofpettemplatebasedandmribasedimageanalysis AT yihsinweng quantitativestudyof18fdtbzimagecomparisonofpettemplatebasedandmribasedimageanalysis AT mingchingwen quantitativestudyof18fdtbzimagecomparisonofpettemplatebasedandmribasedimageanalysis AT ingtsunghsiao quantitativestudyof18fdtbzimagecomparisonofpettemplatebasedandmribasedimageanalysis AT kunjulin quantitativestudyof18fdtbzimagecomparisonofpettemplatebasedandmribasedimageanalysis
_version_	1718388156214018048

Quantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis

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