Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells

Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells

2-Cys peroxiredoxin (Prx) enzymes are highly expressed in most cancers but how they promote cancer progression is unclear. Here the authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradat...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Dong Hoon Kang, Doo Jae Lee, Sunmi Lee, So-Young Lee, Yukyung Jun, Yerin Kim, Youngeun Kim, Ju-Seog Lee, Dae-Kee Lee, Sanghyuk Lee, Eek-Hoon Jho, Dae-Yeul Yu, Sang Won Kang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e27578deda874e92af1b15fb7b61a1bd
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e27578deda874e92af1b15fb7b61a1bd
record_format dspace
spelling oai:doaj.org-article:e27578deda874e92af1b15fb7b61a1bd2021-12-02T14:16:14ZInteraction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells10.1038/s41467-017-00054-02041-1723https://doaj.org/article/e27578deda874e92af1b15fb7b61a1bd2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00054-0https://doaj.org/toc/2041-17232-Cys peroxiredoxin (Prx) enzymes are highly expressed in most cancers but how they promote cancer progression is unclear. Here the authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of ²b-catenin.Dong Hoon KangDoo Jae LeeSunmi LeeSo-Young LeeYukyung JunYerin KimYoungeun KimJu-Seog LeeDae-Kee LeeSanghyuk LeeEek-Hoon JhoDae-Yeul YuSang Won KangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dong Hoon Kang
Doo Jae Lee
Sunmi Lee
So-Young Lee
Yukyung Jun
Yerin Kim
Youngeun Kim
Ju-Seog Lee
Dae-Kee Lee
Sanghyuk Lee
Eek-Hoon Jho
Dae-Yeul Yu
Sang Won Kang
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
description 2-Cys peroxiredoxin (Prx) enzymes are highly expressed in most cancers but how they promote cancer progression is unclear. Here the authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of ²b-catenin.
format article
author Dong Hoon Kang
Doo Jae Lee
Sunmi Lee
So-Young Lee
Yukyung Jun
Yerin Kim
Youngeun Kim
Ju-Seog Lee
Dae-Kee Lee
Sanghyuk Lee
Eek-Hoon Jho
Dae-Yeul Yu
Sang Won Kang
author_facet Dong Hoon Kang
Doo Jae Lee
Sunmi Lee
So-Young Lee
Yukyung Jun
Yerin Kim
Youngeun Kim
Ju-Seog Lee
Dae-Kee Lee
Sanghyuk Lee
Eek-Hoon Jho
Dae-Yeul Yu
Sang Won Kang
author_sort Dong Hoon Kang
title Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
title_short Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
title_full Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
title_fullStr Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
title_full_unstemmed Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
title_sort interaction of tankyrase and peroxiredoxin ii is indispensable for the survival of colorectal cancer cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/e27578deda874e92af1b15fb7b61a1bd
work_keys_str_mv AT donghoonkang interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT doojaelee interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT sunmilee interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT soyounglee interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT yukyungjun interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT yerinkim interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT youngeunkim interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT juseoglee interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT daekeelee interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT sanghyuklee interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT eekhoonjho interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT daeyeulyu interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
AT sangwonkang interactionoftankyraseandperoxiredoxiniiisindispensableforthesurvivalofcolorectalcancercells
_version_ 1718391698001756160

Ejemplares similares