Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes.

<h4>Aim</h4>To evaluate dependence of abnormalities in peripheral nerves and retina in children with type 1 diabetes (T1D) using optical coherence tomography angiography (OCTA) and nerve conduction studies (NCS).<h4>Material and methods</h4>50 adolescents with T1D without any...

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Autores principales:	Marta Wysocka-Mincewicz, Joanna Gołębiewska, Marta Baszyńska-Wilk, Andrzej Olechowski, Aleksandra Byczyńska, Maria Mazur, Monika Nowacka-Gotowiec
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e27646fd34614da8a31cd0d285c8272b
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spelling	oai:doaj.org-article:e27646fd34614da8a31cd0d285c8272b2021-12-02T20:11:03ZAssociations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes.1932-620310.1371/journal.pone.0252588https://doaj.org/article/e27646fd34614da8a31cd0d285c8272b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252588https://doaj.org/toc/1932-6203<h4>Aim</h4>To evaluate dependence of abnormalities in peripheral nerves and retina in children with type 1 diabetes (T1D) using optical coherence tomography angiography (OCTA) and nerve conduction studies (NCS).<h4>Material and methods</h4>50 adolescents with T1D without any signs and symptoms of diabetic retinopathy and neuropathy (mean age 16.92±1.6 years, diabetes duration 6.88 ±4.34years) were included. In OCTA capillary plexuses superficial (SCP) and deep (DCP) vessel density: whole, foveal and parafoveal, ganglion cell complex (GCC), loss volume focal (FLV) and global loss volume (GLV) were analyzed in relation to NCS parameters (motor nerves median and tibial potential amplitude (CMAP), velocity (CV), distal latency (DML) and F wave and sensory nerves median and sural potential amplitude (SNAP), CV and distal latency (DSL).<h4>Results</h4>We detected the correlations between median sensory SNAP and GCC (r = -0.3, p <0.04), motor nerves tibial DML and CV and FLV (respectively r = -0.53, p<0.001, and r = -0.34, p<0.05), and median DML and GLV (r = 0.47, p<0.001). Vessel densities were related to changes in motor nerves tibial velocity (whole SCP r = 0.43, p <0.01, parafoveal SCP r = 0.41, p <0.01), CMAP (parafoveal SCP r = -0.35, p<0.03), median DML (whole DC r = 0.36, p<0.03, foveal DCP r = 0.37, p<0.02) and in sensory median SNAP (whole SCP r = -0.31, p<0.05).<h4>Conclusions</h4>In adolescents with T1D without diabetic neuropathy and retinopathy we detected associations between NCS and OCT and OCTA parameters, regarding decreased GCC and density of superficial and deep vessel plexuses in relation to DML and CV and amplitudes of sensory and motor potential.Marta Wysocka-MincewiczJoanna GołębiewskaMarta Baszyńska-WilkAndrzej OlechowskiAleksandra ByczyńskaMaria MazurMonika Nowacka-GotowiecPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252588 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marta Wysocka-Mincewicz Joanna Gołębiewska Marta Baszyńska-Wilk Andrzej Olechowski Aleksandra Byczyńska Maria Mazur Monika Nowacka-Gotowiec Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes.
description	<h4>Aim</h4>To evaluate dependence of abnormalities in peripheral nerves and retina in children with type 1 diabetes (T1D) using optical coherence tomography angiography (OCTA) and nerve conduction studies (NCS).<h4>Material and methods</h4>50 adolescents with T1D without any signs and symptoms of diabetic retinopathy and neuropathy (mean age 16.92±1.6 years, diabetes duration 6.88 ±4.34years) were included. In OCTA capillary plexuses superficial (SCP) and deep (DCP) vessel density: whole, foveal and parafoveal, ganglion cell complex (GCC), loss volume focal (FLV) and global loss volume (GLV) were analyzed in relation to NCS parameters (motor nerves median and tibial potential amplitude (CMAP), velocity (CV), distal latency (DML) and F wave and sensory nerves median and sural potential amplitude (SNAP), CV and distal latency (DSL).<h4>Results</h4>We detected the correlations between median sensory SNAP and GCC (r = -0.3, p <0.04), motor nerves tibial DML and CV and FLV (respectively r = -0.53, p<0.001, and r = -0.34, p<0.05), and median DML and GLV (r = 0.47, p<0.001). Vessel densities were related to changes in motor nerves tibial velocity (whole SCP r = 0.43, p <0.01, parafoveal SCP r = 0.41, p <0.01), CMAP (parafoveal SCP r = -0.35, p<0.03), median DML (whole DC r = 0.36, p<0.03, foveal DCP r = 0.37, p<0.02) and in sensory median SNAP (whole SCP r = -0.31, p<0.05).<h4>Conclusions</h4>In adolescents with T1D without diabetic neuropathy and retinopathy we detected associations between NCS and OCT and OCTA parameters, regarding decreased GCC and density of superficial and deep vessel plexuses in relation to DML and CV and amplitudes of sensory and motor potential.
format	article
author	Marta Wysocka-Mincewicz Joanna Gołębiewska Marta Baszyńska-Wilk Andrzej Olechowski Aleksandra Byczyńska Maria Mazur Monika Nowacka-Gotowiec
author_facet	Marta Wysocka-Mincewicz Joanna Gołębiewska Marta Baszyńska-Wilk Andrzej Olechowski Aleksandra Byczyńska Maria Mazur Monika Nowacka-Gotowiec
author_sort	Marta Wysocka-Mincewicz
title	Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes.
title_short	Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes.
title_full	Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes.
title_fullStr	Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes.
title_full_unstemmed	Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes.
title_sort	associations of nerve conduction parameters and oct angiography results in adolescents with type 1 diabetes.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e27646fd34614da8a31cd0d285c8272b
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Associations of nerve conduction parameters and OCT angiography results in adolescents with type 1 diabetes.

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