Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis
Yue-Long Xu,1,* Xiu-Xiu Li,1,* Su-Jing Zhuang,1 Shi-Feng Guo,1 Jian-Ping Xiang,1 Long Wang,2 Lan Zhou,2 Bin Wu3 1Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, China; 2Department of Neurology, Center for Evidence-Based Medicine and Clinical Research, Taihe Hospita...
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/e27b2a1b32e24c319d3cdeeb775b7338 |
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| Sumario: | Yue-Long Xu,1,* Xiu-Xiu Li,1,* Su-Jing Zhuang,1 Shi-Feng Guo,1 Jian-Ping Xiang,1 Long Wang,2 Lan Zhou,2 Bin Wu3 1Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, China; 2Department of Neurology, Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China; 3Department of Stomatology, People’s Hospital of District Longhua Shenzhen, Shenzhen 518109, Guangdong Province, China *These authors contributed equally to this work Introduction: Previously published articles have suggested that BDNF rs6265 G>A polymorphism is a potential risk factor for epilepsy. However, the results were not consistent. Methods: We conducted a meta-analysis to explore the association between BDNF rs6265 G>A polymorphism and epilepsy risk. Four online databases were searched, and related studies were reviewed from their inception up to June 20, 2017. ORs and corresponding 95% CIs were used to calculate the associations of each genetic model. Overall, 10 case–control publications involving 9,512 subjects were included in this meta-analysis. Results: Significant associations were found between BDNF rs6265 G>A polymorphism and epilepsy (A vs G: OR=0.88, 95% CI=0.83–0.94, P<0.01, I2=0%; GA vs GG: OR=0.88, 95% CI=0.79–0.97, P=0.01, I2=0%; AA vs GG: OR=0.79, 95% CI=0.70–0.90, P<0.01, I2=0%; GA+AA vs GG: OR=0.85, 95% CI=0.77–0.94, P<0.01, I2=0%; AA vs GG+GA: OR=0.85, 95% CI=0.76–0.95, P=0.01, I2=0%). Subgroup analysis also showed similar results in an Asian population. Conclusion: Our meta-analysis indicated that BDNF rs6265 G>A polymorphism might be involved in epilepsy susceptibility, especially in the Asian population. Keywords: brain derived neurotrophic factor, epilepsy, seizure, polymorphism, variant, rs6265, case–control |
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