Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities
Abstract There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than in those without bronchiectasis. Using 2005–2015 data from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause mortal...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/e27b450a1c90424c9d5a64c3b0990717 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:e27b450a1c90424c9d5a64c3b0990717 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:e27b450a1c90424c9d5a64c3b09907172021-12-02T13:26:37ZIncreased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities10.1038/s41598-021-86407-82045-2322https://doaj.org/article/e27b450a1c90424c9d5a64c3b09907172021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86407-8https://doaj.org/toc/2045-2322Abstract There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than in those without bronchiectasis. Using 2005–2015 data from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause mortality in the bronchiectasis cohort relative to the matched cohort. The effect of comorbidities over the study period on the relative mortality was also assessed. All-cause mortality was significantly higher in the bronchiectasis cohort than in the matched cohort (2505/100,000 vs 2142/100,000 person-years, respectively; P < 0.001). Mortality risk was 1.15-fold greater in the bronchiectasis cohort than in the matched cohort (95% confidence interval [CI] 1.09–1.22); mortality was greatest among elderly patients (HR = 1.17, 95% CI 1.10–1.25) and men (HR = 1.19, 95% CI 1.10–1.29). Comorbidities over the study period significantly increased the risk of death in the bronchiectasis cohort relative to the matched cohort: asthma (adjusted HR = 1.20, 95% CI 1.11–1.30), chronic obstructive pulmonary disease (adjusted HR = 1.24, 95% CI 1.15–1.34), pneumonia (adjusted HR = 1.50, 95% CI 1.39–1.63), lung cancer (adjusted HR = 1.85, 95% CI 1.61–2.12), and cardiovascular disease (adjusted HR = 1.34, 95% CI 1.23–1.45). In contrast, there were no significant differences in the risk of death in patients without bronchiectasis-related comorbidities and the matched cohort, except in the case of non-tuberculous mycobacterial infection. In conclusion, all-cause mortality was higher in patients with bronchiectasis cohort than those without bronchiectasis, especially in elderly patients and men. Comorbidities over the study period played a major role in increasing mortality in patients with bronchiectasis relative to those without bronchiectasis.Hayoung ChoiBumhee YangYun Jin KimSooim SinYong Suk JoYoulim KimHye Yun ParkSeung Won RaYeon-Mok OhSung Jun ChungYoomi YeoDong Won ParkTai Sun ParkJi-Yong MoonSang-Heon KimTae-Hyung KimHo Joo YoonJang Won SohnHyun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Hayoung Choi Bumhee Yang Yun Jin Kim Sooim Sin Yong Suk Jo Youlim Kim Hye Yun Park Seung Won Ra Yeon-Mok Oh Sung Jun Chung Yoomi Yeo Dong Won Park Tai Sun Park Ji-Yong Moon Sang-Heon Kim Tae-Hyung Kim Ho Joo Yoon Jang Won Sohn Hyun Lee Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities |
| description |
Abstract There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than in those without bronchiectasis. Using 2005–2015 data from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause mortality in the bronchiectasis cohort relative to the matched cohort. The effect of comorbidities over the study period on the relative mortality was also assessed. All-cause mortality was significantly higher in the bronchiectasis cohort than in the matched cohort (2505/100,000 vs 2142/100,000 person-years, respectively; P < 0.001). Mortality risk was 1.15-fold greater in the bronchiectasis cohort than in the matched cohort (95% confidence interval [CI] 1.09–1.22); mortality was greatest among elderly patients (HR = 1.17, 95% CI 1.10–1.25) and men (HR = 1.19, 95% CI 1.10–1.29). Comorbidities over the study period significantly increased the risk of death in the bronchiectasis cohort relative to the matched cohort: asthma (adjusted HR = 1.20, 95% CI 1.11–1.30), chronic obstructive pulmonary disease (adjusted HR = 1.24, 95% CI 1.15–1.34), pneumonia (adjusted HR = 1.50, 95% CI 1.39–1.63), lung cancer (adjusted HR = 1.85, 95% CI 1.61–2.12), and cardiovascular disease (adjusted HR = 1.34, 95% CI 1.23–1.45). In contrast, there were no significant differences in the risk of death in patients without bronchiectasis-related comorbidities and the matched cohort, except in the case of non-tuberculous mycobacterial infection. In conclusion, all-cause mortality was higher in patients with bronchiectasis cohort than those without bronchiectasis, especially in elderly patients and men. Comorbidities over the study period played a major role in increasing mortality in patients with bronchiectasis relative to those without bronchiectasis. |
| format |
article |
| author |
Hayoung Choi Bumhee Yang Yun Jin Kim Sooim Sin Yong Suk Jo Youlim Kim Hye Yun Park Seung Won Ra Yeon-Mok Oh Sung Jun Chung Yoomi Yeo Dong Won Park Tai Sun Park Ji-Yong Moon Sang-Heon Kim Tae-Hyung Kim Ho Joo Yoon Jang Won Sohn Hyun Lee |
| author_facet |
Hayoung Choi Bumhee Yang Yun Jin Kim Sooim Sin Yong Suk Jo Youlim Kim Hye Yun Park Seung Won Ra Yeon-Mok Oh Sung Jun Chung Yoomi Yeo Dong Won Park Tai Sun Park Ji-Yong Moon Sang-Heon Kim Tae-Hyung Kim Ho Joo Yoon Jang Won Sohn Hyun Lee |
| author_sort |
Hayoung Choi |
| title |
Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities |
| title_short |
Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities |
| title_full |
Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities |
| title_fullStr |
Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities |
| title_full_unstemmed |
Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities |
| title_sort |
increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e27b450a1c90424c9d5a64c3b0990717 |
| work_keys_str_mv |
AT hayoungchoi increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT bumheeyang increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT yunjinkim increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT sooimsin increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT yongsukjo increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT youlimkim increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT hyeyunpark increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT seungwonra increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT yeonmokoh increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT sungjunchung increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT yoomiyeo increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT dongwonpark increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT taisunpark increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT jiyongmoon increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT sangheonkim increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT taehyungkim increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT hojooyoon increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT jangwonsohn increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities AT hyunlee increasedmortalityinpatientswithnoncysticfibrosisbronchiectasiswithrespiratorycomorbidities |
| _version_ |
1718393065138290688 |