Perturbation-response genes reveal signaling footprints in cancer gene expression

Deregulation of signalling is responsible for many cancer phenotypes. Leveraging available perturbation data, here the authors assess large-scale pathway activity patterns based on consensus downstream readout genes, enabling accurate prediction of the effects of mutations and small molecules.

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Autores principales:	Michael Schubert, Bertram Klinger, Martina Klünemann, Anja Sieber, Florian Uhlitz, Sascha Sauer, Mathew J. Garnett, Nils Blüthgen, Julio Saez-Rodriguez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e27e25be167a4eeb93814f6423e6cf86
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spelling	oai:doaj.org-article:e27e25be167a4eeb93814f6423e6cf862021-12-02T17:31:29ZPerturbation-response genes reveal signaling footprints in cancer gene expression10.1038/s41467-017-02391-62041-1723https://doaj.org/article/e27e25be167a4eeb93814f6423e6cf862018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02391-6https://doaj.org/toc/2041-1723Deregulation of signalling is responsible for many cancer phenotypes. Leveraging available perturbation data, here the authors assess large-scale pathway activity patterns based on consensus downstream readout genes, enabling accurate prediction of the effects of mutations and small molecules.Michael SchubertBertram KlingerMartina KlünemannAnja SieberFlorian UhlitzSascha SauerMathew J. GarnettNils BlüthgenJulio Saez-RodriguezNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Schubert Bertram Klinger Martina Klünemann Anja Sieber Florian Uhlitz Sascha Sauer Mathew J. Garnett Nils Blüthgen Julio Saez-Rodriguez Perturbation-response genes reveal signaling footprints in cancer gene expression
description	Deregulation of signalling is responsible for many cancer phenotypes. Leveraging available perturbation data, here the authors assess large-scale pathway activity patterns based on consensus downstream readout genes, enabling accurate prediction of the effects of mutations and small molecules.
format	article
author	Michael Schubert Bertram Klinger Martina Klünemann Anja Sieber Florian Uhlitz Sascha Sauer Mathew J. Garnett Nils Blüthgen Julio Saez-Rodriguez
author_facet	Michael Schubert Bertram Klinger Martina Klünemann Anja Sieber Florian Uhlitz Sascha Sauer Mathew J. Garnett Nils Blüthgen Julio Saez-Rodriguez
author_sort	Michael Schubert
title	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_short	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_full	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_fullStr	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_full_unstemmed	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_sort	perturbation-response genes reveal signaling footprints in cancer gene expression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e27e25be167a4eeb93814f6423e6cf86
work_keys_str_mv	AT michaelschubert perturbationresponsegenesrevealsignalingfootprintsincancergeneexpression AT bertramklinger perturbationresponsegenesrevealsignalingfootprintsincancergeneexpression AT martinaklunemann perturbationresponsegenesrevealsignalingfootprintsincancergeneexpression AT anjasieber perturbationresponsegenesrevealsignalingfootprintsincancergeneexpression AT florianuhlitz perturbationresponsegenesrevealsignalingfootprintsincancergeneexpression AT saschasauer perturbationresponsegenesrevealsignalingfootprintsincancergeneexpression AT mathewjgarnett perturbationresponsegenesrevealsignalingfootprintsincancergeneexpression AT nilsbluthgen perturbationresponsegenesrevealsignalingfootprintsincancergeneexpression AT juliosaezrodriguez perturbationresponsegenesrevealsignalingfootprintsincancergeneexpression
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Perturbation-response genes reveal signaling footprints in cancer gene expression

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