Prescribing of meprobamate-containing combination analgesics in South Africa

Background: Meprobamate is a constituent of various combination analgesics in South Africa. Due to the lack of recent literature on the prescribing patterns of combination analgesics containing meprobamate and in the light of its possible higher re-scheduling, this study was conducted. The primary a...

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Autor principal:	I. Truter
Formato:	article
Lenguaje:	EN
Publicado:	AOSIS 2016
Materias:	combination analgesics drug utilisation meprobamate polycomponent analgesics prescribing patterns Medicine R
Acceso en línea:	https://doaj.org/article/e27e9e60b00f4c07a644d4d3e238869f
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spelling	oai:doaj.org-article:e27e9e60b00f4c07a644d4d3e238869f2021-11-24T07:44:19ZPrescribing of meprobamate-containing combination analgesics in South Africa2078-61902078-620410.4102/safp.v58i6.4609https://doaj.org/article/e27e9e60b00f4c07a644d4d3e238869f2016-12-01T00:00:00Zhttps://safpj.co.za/index.php/safpj/article/view/4609https://doaj.org/toc/2078-6190https://doaj.org/toc/2078-6204Background: Meprobamate is a constituent of various combination analgesics in South Africa. Due to the lack of recent literature on the prescribing patterns of combination analgesics containing meprobamate and in the light of its possible higher re-scheduling, this study was conducted. The primary aim was to establish the extent of meprobamate-containing combination analgesic prescribing using a prescription claims database. Methods: A retrospective, cross-sectional drug utilisation study was conducted on prescription data of a medical insurance scheme administrator in South Africa for 2011. Results: A total of 31,854 patients received 97,491 analgesics during 2011. Within ATC category N02B, 62.10% of prescriptions were for analgesic combinations, of which 20,326 prescriptions were for meprobamate-containing analgesics. A total of 10,404 patients (53.00% males) were prescribed meprobamate-containing analgesics. Overall, 20.85% of all analgesics prescribed were therefore meprobamate-containing analgesics. Patients who received meprobamate-containing analgesics were slightly older (39.52 years) compared with patients who received analgesics in general (33.61 years). Twenty-two trade names of meprobamate-containing analgesics were prescribed. Seventeen of these products contained exactly the same strengths of active ingredients, namely 320 mg paracetamol, 8 mg codeine phosphate, 32 mg caffeine and 150 mg meprobamate. The originator product constituted 3.72% of prescribing frequency (average cost: R30.42) compared with 70.63% for the most popular generic (average cost: R11.65). Conclusions: Prescribers should be conscious of the benefits and risks of the active ingredient combinations. Further studies including patient and prescriber perceptions of different combinations are recommended.I. TruterAOSISarticlecombination analgesicsdrug utilisationmeprobamatepolycomponent analgesicsprescribing patternsMedicineRENSouth African Family Practice, Vol 58, Iss 6, Pp 1-6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	combination analgesics drug utilisation meprobamate polycomponent analgesics prescribing patterns Medicine R
spellingShingle	combination analgesics drug utilisation meprobamate polycomponent analgesics prescribing patterns Medicine R I. Truter Prescribing of meprobamate-containing combination analgesics in South Africa
description	Background: Meprobamate is a constituent of various combination analgesics in South Africa. Due to the lack of recent literature on the prescribing patterns of combination analgesics containing meprobamate and in the light of its possible higher re-scheduling, this study was conducted. The primary aim was to establish the extent of meprobamate-containing combination analgesic prescribing using a prescription claims database. Methods: A retrospective, cross-sectional drug utilisation study was conducted on prescription data of a medical insurance scheme administrator in South Africa for 2011. Results: A total of 31,854 patients received 97,491 analgesics during 2011. Within ATC category N02B, 62.10% of prescriptions were for analgesic combinations, of which 20,326 prescriptions were for meprobamate-containing analgesics. A total of 10,404 patients (53.00% males) were prescribed meprobamate-containing analgesics. Overall, 20.85% of all analgesics prescribed were therefore meprobamate-containing analgesics. Patients who received meprobamate-containing analgesics were slightly older (39.52 years) compared with patients who received analgesics in general (33.61 years). Twenty-two trade names of meprobamate-containing analgesics were prescribed. Seventeen of these products contained exactly the same strengths of active ingredients, namely 320 mg paracetamol, 8 mg codeine phosphate, 32 mg caffeine and 150 mg meprobamate. The originator product constituted 3.72% of prescribing frequency (average cost: R30.42) compared with 70.63% for the most popular generic (average cost: R11.65). Conclusions: Prescribers should be conscious of the benefits and risks of the active ingredient combinations. Further studies including patient and prescriber perceptions of different combinations are recommended.
format	article
author	I. Truter
author_facet	I. Truter
author_sort	I. Truter
title	Prescribing of meprobamate-containing combination analgesics in South Africa
title_short	Prescribing of meprobamate-containing combination analgesics in South Africa
title_full	Prescribing of meprobamate-containing combination analgesics in South Africa
title_fullStr	Prescribing of meprobamate-containing combination analgesics in South Africa
title_full_unstemmed	Prescribing of meprobamate-containing combination analgesics in South Africa
title_sort	prescribing of meprobamate-containing combination analgesics in south africa
publisher	AOSIS
publishDate	2016
url	https://doaj.org/article/e27e9e60b00f4c07a644d4d3e238869f
work_keys_str_mv	AT itruter prescribingofmeprobamatecontainingcombinationanalgesicsinsouthafrica
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Prescribing of meprobamate-containing combination analgesics in South Africa

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