Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.

Vulvovaginal candidiasis (VVC) is one of the most prevalent vaginal infectious diseases, and there are controversial reports regarding the diversity of the associated vaginal microbiota. We determined the vaginal microbial community in patients with VVC, bacterial vaginosis (BV), and mixed infection...

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Autores principales:	Mu-Biao Liu, Su-Rong Xu, Yan He, Guan-Hua Deng, Hua-Fang Sheng, Xue-Mei Huang, Cai-Yan Ouyang, Hong-Wei Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e28054dd5cd04dbd8a6d5c9b53343e21
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spelling	oai:doaj.org-article:e28054dd5cd04dbd8a6d5c9b53343e212021-11-18T08:47:06ZDiverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.1932-620310.1371/journal.pone.0079812https://doaj.org/article/e28054dd5cd04dbd8a6d5c9b53343e212013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265786/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Vulvovaginal candidiasis (VVC) is one of the most prevalent vaginal infectious diseases, and there are controversial reports regarding the diversity of the associated vaginal microbiota. We determined the vaginal microbial community in patients with VVC, bacterial vaginosis (BV), and mixed infection of VVC and BV using Illumina sequencing of 16S rRNA tags. Our results revealed for the first time the highly variable patterns of the vaginal microbiome from VVC patients. In general, the alpha-diversity results of species richness and evenness showed the following order: normal control < VVC only < mixed BV and VVC infection < BV only. The beta-diversity comparison of community structures also showed an intermediate composition of VVC between the control and BV samples. A detailed comparison showed that, although the control and BV communities had typical patterns, the vaginal microbiota of VVC is complex. The mixed BV and VVC infection group showed a unique pattern, with a relatively higher abundance of Lactobacillus than the BV group and higher abundance of Prevotella, Gardnerella, and Atopobium than the normal control. In contrast, the VVC-only group could not be described by any single profile, ranging from a community structure similar to the normal control (predominated with Lactobacillus) to BV-like community structures (abundant with Gardnerella and Atopobium). Treatment of VVC resulted in inconsistent changes of the vaginal microbiota, with four BV/VVC samples recovering to a higher Lactobacillus level, whereas many VVC-only patients did not. These results will be useful for future studies on the role of vaginal microbiota in VVC and related infectious diseases.Mu-Biao LiuSu-Rong XuYan HeGuan-Hua DengHua-Fang ShengXue-Mei HuangCai-Yan OuyangHong-Wei ZhouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79812 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mu-Biao Liu Su-Rong Xu Yan He Guan-Hua Deng Hua-Fang Sheng Xue-Mei Huang Cai-Yan Ouyang Hong-Wei Zhou Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.
description	Vulvovaginal candidiasis (VVC) is one of the most prevalent vaginal infectious diseases, and there are controversial reports regarding the diversity of the associated vaginal microbiota. We determined the vaginal microbial community in patients with VVC, bacterial vaginosis (BV), and mixed infection of VVC and BV using Illumina sequencing of 16S rRNA tags. Our results revealed for the first time the highly variable patterns of the vaginal microbiome from VVC patients. In general, the alpha-diversity results of species richness and evenness showed the following order: normal control < VVC only < mixed BV and VVC infection < BV only. The beta-diversity comparison of community structures also showed an intermediate composition of VVC between the control and BV samples. A detailed comparison showed that, although the control and BV communities had typical patterns, the vaginal microbiota of VVC is complex. The mixed BV and VVC infection group showed a unique pattern, with a relatively higher abundance of Lactobacillus than the BV group and higher abundance of Prevotella, Gardnerella, and Atopobium than the normal control. In contrast, the VVC-only group could not be described by any single profile, ranging from a community structure similar to the normal control (predominated with Lactobacillus) to BV-like community structures (abundant with Gardnerella and Atopobium). Treatment of VVC resulted in inconsistent changes of the vaginal microbiota, with four BV/VVC samples recovering to a higher Lactobacillus level, whereas many VVC-only patients did not. These results will be useful for future studies on the role of vaginal microbiota in VVC and related infectious diseases.
format	article
author	Mu-Biao Liu Su-Rong Xu Yan He Guan-Hua Deng Hua-Fang Sheng Xue-Mei Huang Cai-Yan Ouyang Hong-Wei Zhou
author_facet	Mu-Biao Liu Su-Rong Xu Yan He Guan-Hua Deng Hua-Fang Sheng Xue-Mei Huang Cai-Yan Ouyang Hong-Wei Zhou
author_sort	Mu-Biao Liu
title	Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.
title_short	Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.
title_full	Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.
title_fullStr	Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.
title_full_unstemmed	Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.
title_sort	diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e28054dd5cd04dbd8a6d5c9b53343e21
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Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.

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