An integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitors.

Matrix metalloproteinases are a family of Zn-proteases involved in tissue remodeling and in many pathological conditions. Among them MMP-2 is one of the most relevant target in anticancer therapy. Commonly, MMP inhibitors contain a functional group able to bind the zinc ion and responsible for undes...

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Autores principales: Antonella Di Pizio, Mariangela Agamennone, Massimiliano Aschi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/e28085eebf9c4d65874dabe5e048c468
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