An integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitors.
Matrix metalloproteinases are a family of Zn-proteases involved in tissue remodeling and in many pathological conditions. Among them MMP-2 is one of the most relevant target in anticancer therapy. Commonly, MMP inhibitors contain a functional group able to bind the zinc ion and responsible for undes...
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Autores principales: | Antonella Di Pizio, Mariangela Agamennone, Massimiliano Aschi |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/e28085eebf9c4d65874dabe5e048c468 |
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