Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men

Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of...

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Autores principales:	K. Barbara Sahlin, Indira Pla, Jéssica de Siqueira Guedes, Krzysztof Pawłowski, Roger Appelqvist, György Marko-Varga, Gilberto Barbosa Domont, Fábio César Sousa Nogueira, Aleksander Giwercman, Aniel Sanchez, Johan Malm
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	testosterone protein breakdown gluconeogenesis Science Q
Acceso en línea:	https://doaj.org/article/e28457666df24296b14f629d39dd9994
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spelling	oai:doaj.org-article:e28457666df24296b14f629d39dd99942021-11-25T18:11:47ZShort-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men10.3390/life111112762075-1729https://doaj.org/article/e28457666df24296b14f629d39dd99942021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1276https://doaj.org/toc/2075-1729Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations.K. Barbara SahlinIndira PlaJéssica de Siqueira GuedesKrzysztof PawłowskiRoger AppelqvistGyörgy Marko-VargaGilberto Barbosa DomontFábio César Sousa NogueiraAleksander GiwercmanAniel SanchezJohan MalmMDPI AGarticletestosteroneprotein breakdowngluconeogenesisScienceQENLife, Vol 11, Iss 1276, p 1276 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	testosterone protein breakdown gluconeogenesis Science Q
spellingShingle	testosterone protein breakdown gluconeogenesis Science Q K. Barbara Sahlin Indira Pla Jéssica de Siqueira Guedes Krzysztof Pawłowski Roger Appelqvist György Marko-Varga Gilberto Barbosa Domont Fábio César Sousa Nogueira Aleksander Giwercman Aniel Sanchez Johan Malm Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men
description	Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations.
format	article
author	K. Barbara Sahlin Indira Pla Jéssica de Siqueira Guedes Krzysztof Pawłowski Roger Appelqvist György Marko-Varga Gilberto Barbosa Domont Fábio César Sousa Nogueira Aleksander Giwercman Aniel Sanchez Johan Malm
author_facet	K. Barbara Sahlin Indira Pla Jéssica de Siqueira Guedes Krzysztof Pawłowski Roger Appelqvist György Marko-Varga Gilberto Barbosa Domont Fábio César Sousa Nogueira Aleksander Giwercman Aniel Sanchez Johan Malm
author_sort	K. Barbara Sahlin
title	Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men
title_short	Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men
title_full	Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men
title_fullStr	Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men
title_full_unstemmed	Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men
title_sort	short-term effect of induced alterations in testosterone levels on fasting plasma amino acid levels in healthy young men
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e28457666df24296b14f629d39dd9994
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Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men

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