YAP1/TAZ drives ependymoma-like tumour formation in mice

YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.

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Autores principales:	Noreen Eder, Federico Roncaroli, Marie-Charlotte Domart, Stuart Horswell, Felipe Andreiuolo, Helen R. Flynn, Andre T. Lopes, Suzanne Claxton, John-Paul Kilday, Lucy Collinson, Jun-Hao Mao, Torsten Pietsch, Barry Thompson, Ambrosius P. Snijders, Sila K. Ultanir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e28a2ae9a5014ff08a75f121065097ec
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spelling	oai:doaj.org-article:e28a2ae9a5014ff08a75f121065097ec2021-12-02T17:16:10ZYAP1/TAZ drives ependymoma-like tumour formation in mice10.1038/s41467-020-16167-y2041-1723https://doaj.org/article/e28a2ae9a5014ff08a75f121065097ec2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16167-yhttps://doaj.org/toc/2041-1723YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.Noreen EderFederico RoncaroliMarie-Charlotte DomartStuart HorswellFelipe AndreiuoloHelen R. FlynnAndre T. LopesSuzanne ClaxtonJohn-Paul KildayLucy CollinsonJun-Hao MaoTorsten PietschBarry ThompsonAmbrosius P. SnijdersSila K. UltanirNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noreen Eder Federico Roncaroli Marie-Charlotte Domart Stuart Horswell Felipe Andreiuolo Helen R. Flynn Andre T. Lopes Suzanne Claxton John-Paul Kilday Lucy Collinson Jun-Hao Mao Torsten Pietsch Barry Thompson Ambrosius P. Snijders Sila K. Ultanir YAP1/TAZ drives ependymoma-like tumour formation in mice
description	YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.
format	article
author	Noreen Eder Federico Roncaroli Marie-Charlotte Domart Stuart Horswell Felipe Andreiuolo Helen R. Flynn Andre T. Lopes Suzanne Claxton John-Paul Kilday Lucy Collinson Jun-Hao Mao Torsten Pietsch Barry Thompson Ambrosius P. Snijders Sila K. Ultanir
author_facet	Noreen Eder Federico Roncaroli Marie-Charlotte Domart Stuart Horswell Felipe Andreiuolo Helen R. Flynn Andre T. Lopes Suzanne Claxton John-Paul Kilday Lucy Collinson Jun-Hao Mao Torsten Pietsch Barry Thompson Ambrosius P. Snijders Sila K. Ultanir
author_sort	Noreen Eder
title	YAP1/TAZ drives ependymoma-like tumour formation in mice
title_short	YAP1/TAZ drives ependymoma-like tumour formation in mice
title_full	YAP1/TAZ drives ependymoma-like tumour formation in mice
title_fullStr	YAP1/TAZ drives ependymoma-like tumour formation in mice
title_full_unstemmed	YAP1/TAZ drives ependymoma-like tumour formation in mice
title_sort	yap1/taz drives ependymoma-like tumour formation in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e28a2ae9a5014ff08a75f121065097ec
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YAP1/TAZ drives ependymoma-like tumour formation in mice

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