A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties

The coumarin nucleus is a recurring motif in both natural and synthetic compounds that exhibit a broad spectrum of biological properties including anticoagulant, anti-inflammatory, antioxidant, antiviral, antimicrobial and anticancer agents as well as enzyme inhibitors. On the other hand, it has bee...

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Autores principales: Łukasz Balewski, Sylwia Szulta, Aleksandra Jalińska, Anita Kornicka
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Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/e28b27cbd51a4be89cca7b0fbdc1c18d
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spelling oai:doaj.org-article:e28b27cbd51a4be89cca7b0fbdc1c18d2021-12-01T23:04:45ZA Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties2296-264610.3389/fchem.2021.781779https://doaj.org/article/e28b27cbd51a4be89cca7b0fbdc1c18d2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.781779/fullhttps://doaj.org/toc/2296-2646The coumarin nucleus is a recurring motif in both natural and synthetic compounds that exhibit a broad spectrum of biological properties including anticoagulant, anti-inflammatory, antioxidant, antiviral, antimicrobial and anticancer agents as well as enzyme inhibitors. On the other hand, it has been reported that the incorporation of a metal ion into coumarin derivatives can increase the activity of such complexes compared to coumarin-based ligands. Accordingly, some of them have been found to display promising antioxidant, antitumor or antibacterial activities. This mini-review briefly summarizes the recent development of coumarin-metal complexes with proven biological properties. The attention is also paid to agents for which practical applications in the detection of biologically important species may be found.Łukasz BalewskiSylwia SzultaAleksandra JalińskaAnita KornickaFrontiers Media S.A.articlecoumarin2H-chromen-2-onemetal complexesbiological activityfluorescent propertiesChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution DOAJ
collection DOAJ
language EN
topic coumarin
2H-chromen-2-one
metal complexes
biological activity
fluorescent properties
Chemistry
QD1-999
spellingShingle coumarin
2H-chromen-2-one
metal complexes
biological activity
fluorescent properties
Chemistry
QD1-999
Łukasz Balewski
Sylwia Szulta
Aleksandra Jalińska
Anita Kornicka
A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties
description The coumarin nucleus is a recurring motif in both natural and synthetic compounds that exhibit a broad spectrum of biological properties including anticoagulant, anti-inflammatory, antioxidant, antiviral, antimicrobial and anticancer agents as well as enzyme inhibitors. On the other hand, it has been reported that the incorporation of a metal ion into coumarin derivatives can increase the activity of such complexes compared to coumarin-based ligands. Accordingly, some of them have been found to display promising antioxidant, antitumor or antibacterial activities. This mini-review briefly summarizes the recent development of coumarin-metal complexes with proven biological properties. The attention is also paid to agents for which practical applications in the detection of biologically important species may be found.
format article
author Łukasz Balewski
Sylwia Szulta
Aleksandra Jalińska
Anita Kornicka
author_facet Łukasz Balewski
Sylwia Szulta
Aleksandra Jalińska
Anita Kornicka
author_sort Łukasz Balewski
title A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties
title_short A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties
title_full A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties
title_fullStr A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties
title_full_unstemmed A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties
title_sort mini-review: recent advances in coumarin-metal complexes with biological properties
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/e28b27cbd51a4be89cca7b0fbdc1c18d
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