Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, the authors conduct pan-cancer analyses and apply statistical modelling to identify 27 candidate tumour suppressors, including MAFTRR, KIAA1551, and IGF2BP2.
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Nature Portfolio
2017
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oai:doaj.org-article:e28c2813abff4f109325d96bafff39762021-12-02T17:06:17ZPan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors10.1038/s41467-017-01355-02041-1723https://doaj.org/article/e28c2813abff4f109325d96bafff39762017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01355-0https://doaj.org/toc/2041-1723Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, the authors conduct pan-cancer analyses and apply statistical modelling to identify 27 candidate tumour suppressors, including MAFTRR, KIAA1551, and IGF2BP2.Jiqiu ChengJonas DemeulemeesterDavid C. WedgeHans Kristian M. VollanJason J. PittHege G. RussnesBina P. PandeyGro NilsenSilje NordGraham R. BignellKevin P. WhiteAnne-Lise Børresen-DalePeter J. CampbellVessela N. KristensenMichael R. StrattonOle Christian LingjærdeYves MoreauPeter Van LooNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jiqiu Cheng Jonas Demeulemeester David C. Wedge Hans Kristian M. Vollan Jason J. Pitt Hege G. Russnes Bina P. Pandey Gro Nilsen Silje Nord Graham R. Bignell Kevin P. White Anne-Lise Børresen-Dale Peter J. Campbell Vessela N. Kristensen Michael R. Stratton Ole Christian Lingjærde Yves Moreau Peter Van Loo Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors |
| description |
Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, the authors conduct pan-cancer analyses and apply statistical modelling to identify 27 candidate tumour suppressors, including MAFTRR, KIAA1551, and IGF2BP2. |
| format |
article |
| author |
Jiqiu Cheng Jonas Demeulemeester David C. Wedge Hans Kristian M. Vollan Jason J. Pitt Hege G. Russnes Bina P. Pandey Gro Nilsen Silje Nord Graham R. Bignell Kevin P. White Anne-Lise Børresen-Dale Peter J. Campbell Vessela N. Kristensen Michael R. Stratton Ole Christian Lingjærde Yves Moreau Peter Van Loo |
| author_facet |
Jiqiu Cheng Jonas Demeulemeester David C. Wedge Hans Kristian M. Vollan Jason J. Pitt Hege G. Russnes Bina P. Pandey Gro Nilsen Silje Nord Graham R. Bignell Kevin P. White Anne-Lise Børresen-Dale Peter J. Campbell Vessela N. Kristensen Michael R. Stratton Ole Christian Lingjærde Yves Moreau Peter Van Loo |
| author_sort |
Jiqiu Cheng |
| title |
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors |
| title_short |
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors |
| title_full |
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors |
| title_fullStr |
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors |
| title_full_unstemmed |
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors |
| title_sort |
pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/e28c2813abff4f109325d96bafff3976 |
| work_keys_str_mv |
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