Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study

Abstract Glomerular filtration rate (GFR) declines with age by approx. 1 ml/min/m2 per year beginning in the third decade of life. At 70 years of age > 40 ml/min/m2 of GFR will be lost. Thus, factors affecting loss of GFR have significant public health implications. Furthermore, the definition of...

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Autores principales:	Thomas Waas, Andreas Schulz, Johannes Lotz, Heidi Rossmann, Norbert Pfeiffer, Manfred E. Beutel, Irene Schmidtmann, Thomas Münzel, Philipp S. Wild, Karl J. Lackner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e291b122a76645df8b27b7d0277ff8f4
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spelling	oai:doaj.org-article:e291b122a76645df8b27b7d0277ff8f42021-12-02T15:55:08ZDistribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study10.1038/s41598-021-89442-72045-2322https://doaj.org/article/e291b122a76645df8b27b7d0277ff8f42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89442-7https://doaj.org/toc/2045-2322Abstract Glomerular filtration rate (GFR) declines with age by approx. 1 ml/min/m2 per year beginning in the third decade of life. At 70 years of age > 40 ml/min/m2 of GFR will be lost. Thus, factors affecting loss of GFR have significant public health implications. Furthermore, the definition of chronic kidney disease based on GFR may not be appropriate for the elderly. We analyzed factors affecting absolute and relative change of eGFR over a 5 year period in 12,381 participants of the Gutenberg Health Study. We estimated GFR at baseline and after 5 years of follow-up by two different equations. Association with the decline of estimated GFR (eGFR) was assessed by multivariable regression analysis. We confirmed a median loss of eGFR per year of approx. 1 ml/min/m2. Aside from albuminuria systolic blood pressure was most strongly associated with faster decline of eGFR followed by echocardiographic evidence of left ventricular diastolic dysfunction and reduced ejection fraction. White blood cell count showed a moderate association with eGFR loss. Diastolic blood pressure, serum uric acid and serum albumin were associated with slower GFR decline in multivariable analysis. Sensitivity analysis with exclusion of individuals taking diuretics, antihypertensive, antidiabetic, or lipid lowering drugs confirmed these associations.Thomas WaasAndreas SchulzJohannes LotzHeidi RossmannNorbert PfeifferManfred E. BeutelIrene SchmidtmannThomas MünzelPhilipp S. WildKarl J. LacknerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas Waas Andreas Schulz Johannes Lotz Heidi Rossmann Norbert Pfeiffer Manfred E. Beutel Irene Schmidtmann Thomas Münzel Philipp S. Wild Karl J. Lackner Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
description	Abstract Glomerular filtration rate (GFR) declines with age by approx. 1 ml/min/m2 per year beginning in the third decade of life. At 70 years of age > 40 ml/min/m2 of GFR will be lost. Thus, factors affecting loss of GFR have significant public health implications. Furthermore, the definition of chronic kidney disease based on GFR may not be appropriate for the elderly. We analyzed factors affecting absolute and relative change of eGFR over a 5 year period in 12,381 participants of the Gutenberg Health Study. We estimated GFR at baseline and after 5 years of follow-up by two different equations. Association with the decline of estimated GFR (eGFR) was assessed by multivariable regression analysis. We confirmed a median loss of eGFR per year of approx. 1 ml/min/m2. Aside from albuminuria systolic blood pressure was most strongly associated with faster decline of eGFR followed by echocardiographic evidence of left ventricular diastolic dysfunction and reduced ejection fraction. White blood cell count showed a moderate association with eGFR loss. Diastolic blood pressure, serum uric acid and serum albumin were associated with slower GFR decline in multivariable analysis. Sensitivity analysis with exclusion of individuals taking diuretics, antihypertensive, antidiabetic, or lipid lowering drugs confirmed these associations.
format	article
author	Thomas Waas Andreas Schulz Johannes Lotz Heidi Rossmann Norbert Pfeiffer Manfred E. Beutel Irene Schmidtmann Thomas Münzel Philipp S. Wild Karl J. Lackner
author_facet	Thomas Waas Andreas Schulz Johannes Lotz Heidi Rossmann Norbert Pfeiffer Manfred E. Beutel Irene Schmidtmann Thomas Münzel Philipp S. Wild Karl J. Lackner
author_sort	Thomas Waas
title	Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
title_short	Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
title_full	Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
title_fullStr	Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
title_full_unstemmed	Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
title_sort	distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a german population-based study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e291b122a76645df8b27b7d0277ff8f4
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Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study

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