Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer

Intratumoral immunity heterogeneity is poorly characterized. Here the authors apply exome sequencing, transcriptome profiling and T-cell repertoire profiling to multiple loci of non-small-cell lung cancer patients' biopsies and find high spatial immune heterogeneity with local mutational burden...

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Autores principales:	Qingzhu Jia, Wei Wu, Yuqi Wang, Peter B. Alexander, Chengdu Sun, Zhihua Gong, Jia-Nan Cheng, Huaibo Sun, Yanfang Guan, Xuefeng Xia, Ling Yang, Xin Yi, Yisong Y. Wan, Haidong Wang, Ji He, P. Andrew Futreal, Qi-Jing Li, Bo Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e293331d105f4f4b8efabbf555c989e7
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spelling	oai:doaj.org-article:e293331d105f4f4b8efabbf555c989e72021-12-02T13:27:23ZLocal mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer10.1038/s41467-018-07767-w2041-1723https://doaj.org/article/e293331d105f4f4b8efabbf555c989e72018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07767-whttps://doaj.org/toc/2041-1723Intratumoral immunity heterogeneity is poorly characterized. Here the authors apply exome sequencing, transcriptome profiling and T-cell repertoire profiling to multiple loci of non-small-cell lung cancer patients' biopsies and find high spatial immune heterogeneity with local mutational burden correlating with T-cell clonal expansion but not with cytotoxicity.Qingzhu JiaWei WuYuqi WangPeter B. AlexanderChengdu SunZhihua GongJia-Nan ChengHuaibo SunYanfang GuanXuefeng XiaLing YangXin YiYisong Y. WanHaidong WangJi HeP. Andrew FutrealQi-Jing LiBo ZhuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingzhu Jia Wei Wu Yuqi Wang Peter B. Alexander Chengdu Sun Zhihua Gong Jia-Nan Cheng Huaibo Sun Yanfang Guan Xuefeng Xia Ling Yang Xin Yi Yisong Y. Wan Haidong Wang Ji He P. Andrew Futreal Qi-Jing Li Bo Zhu Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
description	Intratumoral immunity heterogeneity is poorly characterized. Here the authors apply exome sequencing, transcriptome profiling and T-cell repertoire profiling to multiple loci of non-small-cell lung cancer patients' biopsies and find high spatial immune heterogeneity with local mutational burden correlating with T-cell clonal expansion but not with cytotoxicity.
format	article
author	Qingzhu Jia Wei Wu Yuqi Wang Peter B. Alexander Chengdu Sun Zhihua Gong Jia-Nan Cheng Huaibo Sun Yanfang Guan Xuefeng Xia Ling Yang Xin Yi Yisong Y. Wan Haidong Wang Ji He P. Andrew Futreal Qi-Jing Li Bo Zhu
author_facet	Qingzhu Jia Wei Wu Yuqi Wang Peter B. Alexander Chengdu Sun Zhihua Gong Jia-Nan Cheng Huaibo Sun Yanfang Guan Xuefeng Xia Ling Yang Xin Yi Yisong Y. Wan Haidong Wang Ji He P. Andrew Futreal Qi-Jing Li Bo Zhu
author_sort	Qingzhu Jia
title	Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
title_short	Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
title_full	Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
title_fullStr	Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
title_full_unstemmed	Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
title_sort	local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e293331d105f4f4b8efabbf555c989e7
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Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer

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