Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer

Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer

Intratumoral immunity heterogeneity is poorly characterized. Here the authors apply exome sequencing, transcriptome profiling and T-cell repertoire profiling to multiple loci of non-small-cell lung cancer patients' biopsies and find high spatial immune heterogeneity with local mutational burden...

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Main Authors: Qingzhu Jia, Wei Wu, Yuqi Wang, Peter B. Alexander, Chengdu Sun, Zhihua Gong, Jia-Nan Cheng, Huaibo Sun, Yanfang Guan, Xuefeng Xia, Ling Yang, Xin Yi, Yisong Y. Wan, Haidong Wang, Ji He, P. Andrew Futreal, Qi-Jing Li, Bo Zhu
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/e293331d105f4f4b8efabbf555c989e7
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https://doaj.org/article/e293331d105f4f4b8efabbf555c989e7

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