Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.

<h4>Background</h4>Metastasis formation remains an enigmatic process and one of the main questions recently asked is whether metastases are able to generate further metastases. Different models have been proposed to answer this question; however, their clinical significance remains uncle...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anja Bethge, Udo Schumacher, Andreas Wree, Gero Wedemann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e29610a708e84d7fb237d4797920dbad
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e29610a708e84d7fb237d4797920dbad
record_format	dspace
spelling	oai:doaj.org-article:e29610a708e84d7fb237d4797920dbad2021-11-18T07:21:15ZAre metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.1932-620310.1371/journal.pone.0035689https://doaj.org/article/e29610a708e84d7fb237d4797920dbad2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22539992/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Metastasis formation remains an enigmatic process and one of the main questions recently asked is whether metastases are able to generate further metastases. Different models have been proposed to answer this question; however, their clinical significance remains unclear. Therefore a computer model was developed that permits comparison of the different models quantitatively with clinical data and that additionally predicts the outcome of treatment interventions.<h4>Methods</h4>The computer model is based on discrete events simulation approach. On the basis of a case from an untreated patient with hepatocellular carcinoma and its multiple metastases in the liver, it was evaluated whether metastases are able to metastasise and in particular if late disseminated tumour cells are still capable to form metastases. Additionally, the resection of the primary tumour was simulated. The simulation results were compared with clinical data.<h4>Results</h4>The simulation results reveal that the number of metastases varies significantly between scenarios where metastases metastasise and scenarios where they do not. In contrast, the total tumour mass is nearly unaffected by the two different modes of metastasis formation. Furthermore, the results provide evidence that metastasis formation is an early event and that late disseminated tumour cells are still capable of forming metastases. Simulations also allow estimating how the resection of the primary tumour delays the patient's death.<h4>Conclusion</h4>The simulation results indicate that for this particular case of a hepatocellular carcinoma late metastases, i.e., metastases from metastases, are irrelevant in terms of total tumour mass. Hence metastases seeded from metastases are clinically irrelevant in our model system. Only the first metastases seeded from the primary tumour contribute significantly to the tumour burden and thus cause the patient's death.Anja BethgeUdo SchumacherAndreas WreeGero WedemannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35689 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anja Bethge Udo Schumacher Andreas Wree Gero Wedemann Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.
description	<h4>Background</h4>Metastasis formation remains an enigmatic process and one of the main questions recently asked is whether metastases are able to generate further metastases. Different models have been proposed to answer this question; however, their clinical significance remains unclear. Therefore a computer model was developed that permits comparison of the different models quantitatively with clinical data and that additionally predicts the outcome of treatment interventions.<h4>Methods</h4>The computer model is based on discrete events simulation approach. On the basis of a case from an untreated patient with hepatocellular carcinoma and its multiple metastases in the liver, it was evaluated whether metastases are able to metastasise and in particular if late disseminated tumour cells are still capable to form metastases. Additionally, the resection of the primary tumour was simulated. The simulation results were compared with clinical data.<h4>Results</h4>The simulation results reveal that the number of metastases varies significantly between scenarios where metastases metastasise and scenarios where they do not. In contrast, the total tumour mass is nearly unaffected by the two different modes of metastasis formation. Furthermore, the results provide evidence that metastasis formation is an early event and that late disseminated tumour cells are still capable of forming metastases. Simulations also allow estimating how the resection of the primary tumour delays the patient's death.<h4>Conclusion</h4>The simulation results indicate that for this particular case of a hepatocellular carcinoma late metastases, i.e., metastases from metastases, are irrelevant in terms of total tumour mass. Hence metastases seeded from metastases are clinically irrelevant in our model system. Only the first metastases seeded from the primary tumour contribute significantly to the tumour burden and thus cause the patient's death.
format	article
author	Anja Bethge Udo Schumacher Andreas Wree Gero Wedemann
author_facet	Anja Bethge Udo Schumacher Andreas Wree Gero Wedemann
author_sort	Anja Bethge
title	Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.
title_short	Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.
title_full	Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.
title_fullStr	Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.
title_full_unstemmed	Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.
title_sort	are metastases from metastases clinical relevant? computer modelling of cancer spread in a case of hepatocellular carcinoma.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e29610a708e84d7fb237d4797920dbad
work_keys_str_mv	AT anjabethge aremetastasesfrommetastasesclinicalrelevantcomputermodellingofcancerspreadinacaseofhepatocellularcarcinoma AT udoschumacher aremetastasesfrommetastasesclinicalrelevantcomputermodellingofcancerspreadinacaseofhepatocellularcarcinoma AT andreaswree aremetastasesfrommetastasesclinicalrelevantcomputermodellingofcancerspreadinacaseofhepatocellularcarcinoma AT gerowedemann aremetastasesfrommetastasesclinicalrelevantcomputermodellingofcancerspreadinacaseofhepatocellularcarcinoma
_version_	1718423632448847872

Are metastases from metastases clinical relevant? Computer modelling of cancer spread in a case of hepatocellular carcinoma.

Ejemplares similares