Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C

Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C

Linking antibiotic resistance (AR) in the gut microbiome with their bacterial hosts remains challenging. Here, the authors apply bacterial Hi-C to map mobile genetic elements in metagenomes, and illustrate that genes are present in more diverse taxa in neutropenic patients than healthy subjects.

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Auteurs principaux: Alyssa G. Kent, Albert C. Vill, Qiaojuan Shi, Michael J. Satlin, Ilana Lauren Brito
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/e296af1a30b04de1bea63202772c38d8
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spelling oai:doaj.org-article:e296af1a30b04de1bea63202772c38d82021-12-02T15:25:37ZWidespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C10.1038/s41467-020-18164-72041-1723https://doaj.org/article/e296af1a30b04de1bea63202772c38d82020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18164-7https://doaj.org/toc/2041-1723Linking antibiotic resistance (AR) in the gut microbiome with their bacterial hosts remains challenging. Here, the authors apply bacterial Hi-C to map mobile genetic elements in metagenomes, and illustrate that genes are present in more diverse taxa in neutropenic patients than healthy subjects.Alyssa G. KentAlbert C. VillQiaojuan ShiMichael J. SatlinIlana Lauren BritoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alyssa G. Kent
Albert C. Vill
Qiaojuan Shi
Michael J. Satlin
Ilana Lauren Brito
Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C
description Linking antibiotic resistance (AR) in the gut microbiome with their bacterial hosts remains challenging. Here, the authors apply bacterial Hi-C to map mobile genetic elements in metagenomes, and illustrate that genes are present in more diverse taxa in neutropenic patients than healthy subjects.
format article
author Alyssa G. Kent
Albert C. Vill
Qiaojuan Shi
Michael J. Satlin
Ilana Lauren Brito
author_facet Alyssa G. Kent
Albert C. Vill
Qiaojuan Shi
Michael J. Satlin
Ilana Lauren Brito
author_sort Alyssa G. Kent
title Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C
title_short Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C
title_full Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C
title_fullStr Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C
title_full_unstemmed Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C
title_sort widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial hi-c
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/e296af1a30b04de1bea63202772c38d8
work_keys_str_mv AT alyssagkent widespreadtransferofmobileantibioticresistancegeneswithinindividualgutmicrobiomesrevealedthroughbacterialhic
AT albertcvill widespreadtransferofmobileantibioticresistancegeneswithinindividualgutmicrobiomesrevealedthroughbacterialhic
AT qiaojuanshi widespreadtransferofmobileantibioticresistancegeneswithinindividualgutmicrobiomesrevealedthroughbacterialhic
AT michaeljsatlin widespreadtransferofmobileantibioticresistancegeneswithinindividualgutmicrobiomesrevealedthroughbacterialhic
AT ilanalaurenbrito widespreadtransferofmobileantibioticresistancegeneswithinindividualgutmicrobiomesrevealedthroughbacterialhic
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