Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine and exocrine function for up to ten days in culture.

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Autores principales:	Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e297d8d44f204d96a98c13a905c50452
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spelling	oai:doaj.org-article:e297d8d44f204d96a98c13a905c504522021-12-02T16:10:47ZLong-term culture of human pancreatic slices as a model to study real-time islet regeneration10.1038/s41467-020-17040-82041-1723https://doaj.org/article/e297d8d44f204d96a98c13a905c504522020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17040-8https://doaj.org/toc/2041-1723The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine and exocrine function for up to ten days in culture.Mirza Muhammad Fahd QadirSilvia Álvarez-CubelaJonathan WeitzJulia K. PanzerDagmar KleinYaisa Moreno-HernándezSirlene CechinAlejandro TamayoJoana AlmaçaHelmut HillerMaria BeeryIrina KusmartsevaMark AtkinsonStephan SpeierCamillo RicordiAlberto PuglieseAlejandro CaicedoChristopher A. FrakerRicardo Luis PastoriJuan Domínguez-BendalaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mirza Muhammad Fahd Qadir Silvia Álvarez-Cubela Jonathan Weitz Julia K. Panzer Dagmar Klein Yaisa Moreno-Hernández Sirlene Cechin Alejandro Tamayo Joana Almaça Helmut Hiller Maria Beery Irina Kusmartseva Mark Atkinson Stephan Speier Camillo Ricordi Alberto Pugliese Alejandro Caicedo Christopher A. Fraker Ricardo Luis Pastori Juan Domínguez-Bendala Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
description	The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine and exocrine function for up to ten days in culture.
format	article
author	Mirza Muhammad Fahd Qadir Silvia Álvarez-Cubela Jonathan Weitz Julia K. Panzer Dagmar Klein Yaisa Moreno-Hernández Sirlene Cechin Alejandro Tamayo Joana Almaça Helmut Hiller Maria Beery Irina Kusmartseva Mark Atkinson Stephan Speier Camillo Ricordi Alberto Pugliese Alejandro Caicedo Christopher A. Fraker Ricardo Luis Pastori Juan Domínguez-Bendala
author_facet	Mirza Muhammad Fahd Qadir Silvia Álvarez-Cubela Jonathan Weitz Julia K. Panzer Dagmar Klein Yaisa Moreno-Hernández Sirlene Cechin Alejandro Tamayo Joana Almaça Helmut Hiller Maria Beery Irina Kusmartseva Mark Atkinson Stephan Speier Camillo Ricordi Alberto Pugliese Alejandro Caicedo Christopher A. Fraker Ricardo Luis Pastori Juan Domínguez-Bendala
author_sort	Mirza Muhammad Fahd Qadir
title	Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
title_short	Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
title_full	Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
title_fullStr	Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
title_full_unstemmed	Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
title_sort	long-term culture of human pancreatic slices as a model to study real-time islet regeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e297d8d44f204d96a98c13a905c50452
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Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

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