Prognostic value of blood flow measurements using arterial spin labeling in gliomas.

The period of event-free survival (EFS) within the same histopathological glioma grades may have high variability, mainly without a known cause. The purpose of this study was to reveal the prognostic value of quantified tumor blood flow (TBF) values obtained by arterial spin labeling (ASL) for EFS i...

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Autores principales:	Julia Furtner, Benjamin Bender, Christian Braun, Jens Schittenhelm, Marco Skardelly, Ulrike Ernemann, Sotirios Bisdas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e29881dcdcc14ae28db2c2cf291273c8
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spelling	oai:doaj.org-article:e29881dcdcc14ae28db2c2cf291273c82021-11-18T08:16:38ZPrognostic value of blood flow measurements using arterial spin labeling in gliomas.1932-620310.1371/journal.pone.0099616https://doaj.org/article/e29881dcdcc14ae28db2c2cf291273c82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24911025/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The period of event-free survival (EFS) within the same histopathological glioma grades may have high variability, mainly without a known cause. The purpose of this study was to reveal the prognostic value of quantified tumor blood flow (TBF) values obtained by arterial spin labeling (ASL) for EFS in patients with histopathologically proven astrocytomas independent of WHO (World Health Organization) grade. Twenty-four patients with untreated gliomas underwent tumor perfusion quantification by means of pulsed ASL in 3T. The clinical history of the patients was retrospectively extracted from the local database. Six patients had to be excluded due to insufficent follow-up data for further evaluation or histopathologically verified oligodendroglioma tumor components. Receiver operating characteristic (ROC) curves were used to define an optimal cut-off value of maximum TBF (mTBF) values for subgrouping in low-perfused and high-perfused gliomas. Kaplan-Meier curves and Cox proportional hazard regression model were used to determine the prognostic value of mTBF for EFS. An optimal mTBF cut-off value of 182 ml/100 g/min (sensitivity = 83%, specificity = 100%) was determined. Patients with low-perfused gliomas had significantly longer EFS compared to patients with high-perfused gliomas (p = 0.0012) independent of the WHO glioma grade. Quantified mTBF values obtained by ASL offer a new and totally non-invasive marker to prognosticate the EFS, independently on histopathological tumor grading, in patients with gliomas.Julia FurtnerBenjamin BenderChristian BraunJens SchittenhelmMarco SkardellyUlrike ErnemannSotirios BisdasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99616 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia Furtner Benjamin Bender Christian Braun Jens Schittenhelm Marco Skardelly Ulrike Ernemann Sotirios Bisdas Prognostic value of blood flow measurements using arterial spin labeling in gliomas.
description	The period of event-free survival (EFS) within the same histopathological glioma grades may have high variability, mainly without a known cause. The purpose of this study was to reveal the prognostic value of quantified tumor blood flow (TBF) values obtained by arterial spin labeling (ASL) for EFS in patients with histopathologically proven astrocytomas independent of WHO (World Health Organization) grade. Twenty-four patients with untreated gliomas underwent tumor perfusion quantification by means of pulsed ASL in 3T. The clinical history of the patients was retrospectively extracted from the local database. Six patients had to be excluded due to insufficent follow-up data for further evaluation or histopathologically verified oligodendroglioma tumor components. Receiver operating characteristic (ROC) curves were used to define an optimal cut-off value of maximum TBF (mTBF) values for subgrouping in low-perfused and high-perfused gliomas. Kaplan-Meier curves and Cox proportional hazard regression model were used to determine the prognostic value of mTBF for EFS. An optimal mTBF cut-off value of 182 ml/100 g/min (sensitivity = 83%, specificity = 100%) was determined. Patients with low-perfused gliomas had significantly longer EFS compared to patients with high-perfused gliomas (p = 0.0012) independent of the WHO glioma grade. Quantified mTBF values obtained by ASL offer a new and totally non-invasive marker to prognosticate the EFS, independently on histopathological tumor grading, in patients with gliomas.
format	article
author	Julia Furtner Benjamin Bender Christian Braun Jens Schittenhelm Marco Skardelly Ulrike Ernemann Sotirios Bisdas
author_facet	Julia Furtner Benjamin Bender Christian Braun Jens Schittenhelm Marco Skardelly Ulrike Ernemann Sotirios Bisdas
author_sort	Julia Furtner
title	Prognostic value of blood flow measurements using arterial spin labeling in gliomas.
title_short	Prognostic value of blood flow measurements using arterial spin labeling in gliomas.
title_full	Prognostic value of blood flow measurements using arterial spin labeling in gliomas.
title_fullStr	Prognostic value of blood flow measurements using arterial spin labeling in gliomas.
title_full_unstemmed	Prognostic value of blood flow measurements using arterial spin labeling in gliomas.
title_sort	prognostic value of blood flow measurements using arterial spin labeling in gliomas.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e29881dcdcc14ae28db2c2cf291273c8
work_keys_str_mv	AT juliafurtner prognosticvalueofbloodflowmeasurementsusingarterialspinlabelingingliomas AT benjaminbender prognosticvalueofbloodflowmeasurementsusingarterialspinlabelingingliomas AT christianbraun prognosticvalueofbloodflowmeasurementsusingarterialspinlabelingingliomas AT jensschittenhelm prognosticvalueofbloodflowmeasurementsusingarterialspinlabelingingliomas AT marcoskardelly prognosticvalueofbloodflowmeasurementsusingarterialspinlabelingingliomas AT ulrikeernemann prognosticvalueofbloodflowmeasurementsusingarterialspinlabelingingliomas AT sotiriosbisdas prognosticvalueofbloodflowmeasurementsusingarterialspinlabelingingliomas
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Prognostic value of blood flow measurements using arterial spin labeling in gliomas.

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