CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells

CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells

CRISPR-Cas9 generates double-strand breaks, which pose a threat to genome integrity. Here the authors show loss of heterozygosity in edited hematopoietic progenitor cells.

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Autores principales: J. Boutin, J. Rosier, D. Cappellen, F. Prat, J. Toutain, P. Pennamen, J. Bouron, C. Rooryck, J. P. Merlio, I. Lamrissi-Garcia, G. Cullot, S. Amintas, V. Guyonnet-Duperat, C. Ged, J. M. Blouin, E. Richard, S. Dabernat, F. Moreau-Gaudry, A. Bedel
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e2a0368b510f4b0f8a6f33bea02556ca
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spelling oai:doaj.org-article:e2a0368b510f4b0f8a6f33bea02556ca2021-12-02T18:50:59ZCRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells10.1038/s41467-021-25190-62041-1723https://doaj.org/article/e2a0368b510f4b0f8a6f33bea02556ca2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25190-6https://doaj.org/toc/2041-1723CRISPR-Cas9 generates double-strand breaks, which pose a threat to genome integrity. Here the authors show loss of heterozygosity in edited hematopoietic progenitor cells.J. BoutinJ. RosierD. CappellenF. PratJ. ToutainP. PennamenJ. BouronC. RooryckJ. P. MerlioI. Lamrissi-GarciaG. CullotS. AmintasV. Guyonnet-DuperatC. GedJ. M. BlouinE. RichardS. DabernatF. Moreau-GaudryA. BedelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
J. Boutin
J. Rosier
D. Cappellen
F. Prat
J. Toutain
P. Pennamen
J. Bouron
C. Rooryck
J. P. Merlio
I. Lamrissi-Garcia
G. Cullot
S. Amintas
V. Guyonnet-Duperat
C. Ged
J. M. Blouin
E. Richard
S. Dabernat
F. Moreau-Gaudry
A. Bedel
CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
description CRISPR-Cas9 generates double-strand breaks, which pose a threat to genome integrity. Here the authors show loss of heterozygosity in edited hematopoietic progenitor cells.
format article
author J. Boutin
J. Rosier
D. Cappellen
F. Prat
J. Toutain
P. Pennamen
J. Bouron
C. Rooryck
J. P. Merlio
I. Lamrissi-Garcia
G. Cullot
S. Amintas
V. Guyonnet-Duperat
C. Ged
J. M. Blouin
E. Richard
S. Dabernat
F. Moreau-Gaudry
A. Bedel
author_facet J. Boutin
J. Rosier
D. Cappellen
F. Prat
J. Toutain
P. Pennamen
J. Bouron
C. Rooryck
J. P. Merlio
I. Lamrissi-Garcia
G. Cullot
S. Amintas
V. Guyonnet-Duperat
C. Ged
J. M. Blouin
E. Richard
S. Dabernat
F. Moreau-Gaudry
A. Bedel
author_sort J. Boutin
title CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
title_short CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
title_full CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
title_fullStr CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
title_full_unstemmed CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
title_sort crispr-cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e2a0368b510f4b0f8a6f33bea02556ca
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