Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals

Abstract The role of leukocyte inflammatory markers and toll like receptors (TLRs)2/4 in pathologies associated with elevated resting heart rate (RHR) levels in healthy obese (HO) individuals is not well elucidated. Herein, we investigated the relationship of RHR with expression of leukocyte-inflamm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fatema Al-Rashed, Sardar Sindhu, Ashraf Al Madhoun, Zunair Ahmad, Dawood AlMekhled, Rafaat Azim, Sarah Al-Kandari, Maziad Al-Abdul Wahid, Fahd Al-Mulla, Rasheed Ahmad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e2a0f457156243398013c76f594e7552
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e2a0f457156243398013c76f594e7552
record_format	dspace
spelling	oai:doaj.org-article:e2a0f457156243398013c76f594e75522021-12-02T15:39:50ZElevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals10.1038/s41598-021-93449-52045-2322https://doaj.org/article/e2a0f457156243398013c76f594e75522021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93449-5https://doaj.org/toc/2045-2322Abstract The role of leukocyte inflammatory markers and toll like receptors (TLRs)2/4 in pathologies associated with elevated resting heart rate (RHR) levels in healthy obese (HO) individuals is not well elucidated. Herein, we investigated the relationship of RHR with expression of leukocyte-inflammatory markers and TLRs in HO individuals. 58-obese and 57-lean participants with no history of a major medical condition, were recruited in this study. In HO individuals, the elevated-RHR correlated positively with diastolic blood pressure, cholesterol, pro-inflammatory monocytes CD11b+CD11c+CD206− phenotype (r = 0.52, P = 0.0003) as well as with activated T cells CD8+HLA-DR+ phenotype (r = 0.27, P = 0.039). No association was found between RHR and the percentage of CD16+CD11b+ neutrophils. Interestingly, elevated RHR positively correlated with cells expressing TLR4 and TLR2 (CD14+TLR4+, r = 0.51, P ≤ 0.0001; and CD14+TLR2+, r = 0.42, P = 0.001). TLR4+ expressing cells also associated positively with the plasma concentrations of proinflammatory or vascular permeability/matrix modulatory markers including TNF-α (r = 0.36, P = 0.005), VEGF (r = 0.47, P = 0.0002), and MMP-9 (r = 0.53, P ≤ 0.0001). Multiple regression revealed that RHR is independently associated with CD14+TLR4+ monocytes and VEGF. We conclude that in HO individuals, increased CD14+TLR4+ monocytes and circulatory VEGF levels associated independently with RHR, implying that RHR monitoring could be used as a non-invasive clinical indicator to identify healthy obese individuals at an increased risk of developing inflammation and cardiovascular disease.Fatema Al-RashedSardar SindhuAshraf Al MadhounZunair AhmadDawood AlMekhledRafaat AzimSarah Al-KandariMaziad Al-Abdul WahidFahd Al-MullaRasheed AhmadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fatema Al-Rashed Sardar Sindhu Ashraf Al Madhoun Zunair Ahmad Dawood AlMekhled Rafaat Azim Sarah Al-Kandari Maziad Al-Abdul Wahid Fahd Al-Mulla Rasheed Ahmad Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
description	Abstract The role of leukocyte inflammatory markers and toll like receptors (TLRs)2/4 in pathologies associated with elevated resting heart rate (RHR) levels in healthy obese (HO) individuals is not well elucidated. Herein, we investigated the relationship of RHR with expression of leukocyte-inflammatory markers and TLRs in HO individuals. 58-obese and 57-lean participants with no history of a major medical condition, were recruited in this study. In HO individuals, the elevated-RHR correlated positively with diastolic blood pressure, cholesterol, pro-inflammatory monocytes CD11b+CD11c+CD206− phenotype (r = 0.52, P = 0.0003) as well as with activated T cells CD8+HLA-DR+ phenotype (r = 0.27, P = 0.039). No association was found between RHR and the percentage of CD16+CD11b+ neutrophils. Interestingly, elevated RHR positively correlated with cells expressing TLR4 and TLR2 (CD14+TLR4+, r = 0.51, P ≤ 0.0001; and CD14+TLR2+, r = 0.42, P = 0.001). TLR4+ expressing cells also associated positively with the plasma concentrations of proinflammatory or vascular permeability/matrix modulatory markers including TNF-α (r = 0.36, P = 0.005), VEGF (r = 0.47, P = 0.0002), and MMP-9 (r = 0.53, P ≤ 0.0001). Multiple regression revealed that RHR is independently associated with CD14+TLR4+ monocytes and VEGF. We conclude that in HO individuals, increased CD14+TLR4+ monocytes and circulatory VEGF levels associated independently with RHR, implying that RHR monitoring could be used as a non-invasive clinical indicator to identify healthy obese individuals at an increased risk of developing inflammation and cardiovascular disease.
format	article
author	Fatema Al-Rashed Sardar Sindhu Ashraf Al Madhoun Zunair Ahmad Dawood AlMekhled Rafaat Azim Sarah Al-Kandari Maziad Al-Abdul Wahid Fahd Al-Mulla Rasheed Ahmad
author_facet	Fatema Al-Rashed Sardar Sindhu Ashraf Al Madhoun Zunair Ahmad Dawood AlMekhled Rafaat Azim Sarah Al-Kandari Maziad Al-Abdul Wahid Fahd Al-Mulla Rasheed Ahmad
author_sort	Fatema Al-Rashed
title	Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_short	Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_full	Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_fullStr	Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_full_unstemmed	Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
title_sort	elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e2a0f457156243398013c76f594e7552
work_keys_str_mv	AT fatemaalrashed elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals AT sardarsindhu elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals AT ashrafalmadhoun elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals AT zunairahmad elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals AT dawoodalmekhled elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals AT rafaatazim elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals AT sarahalkandari elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals AT maziadalabdulwahid elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals AT fahdalmulla elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals AT rasheedahmad elevatedrestingheartrateasapredictorofinflammationandcardiovascularriskinhealthyobeseindividuals
_version_	1718385905493868544

Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals

Ejemplares similares