Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice

Spermatogonial stem cells have the dual capacity to self-renew and differentiate into mature spermatozoa. Here, using transcriptome analyses of juvenile testes in gene-edited mice, the authors demonstrate that PRAMEF12 is required to maintain germ cell homeostasis and promote their differentiation.

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Autores principales:	Zhengpin Wang, Xiaojiang Xu, Jian-Liang Li, Cameron Palmer, Dragan Maric, Jurrien Dean
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2a52d907b7c4c48af38cd6b40f4377a
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spelling	oai:doaj.org-article:e2a52d907b7c4c48af38cd6b40f4377a2021-12-02T16:57:45ZSertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice10.1038/s41467-019-13193-32041-1723https://doaj.org/article/e2a52d907b7c4c48af38cd6b40f4377a2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13193-3https://doaj.org/toc/2041-1723Spermatogonial stem cells have the dual capacity to self-renew and differentiate into mature spermatozoa. Here, using transcriptome analyses of juvenile testes in gene-edited mice, the authors demonstrate that PRAMEF12 is required to maintain germ cell homeostasis and promote their differentiation.Zhengpin WangXiaojiang XuJian-Liang LiCameron PalmerDragan MaricJurrien DeanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhengpin Wang Xiaojiang Xu Jian-Liang Li Cameron Palmer Dragan Maric Jurrien Dean Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice
description	Spermatogonial stem cells have the dual capacity to self-renew and differentiate into mature spermatozoa. Here, using transcriptome analyses of juvenile testes in gene-edited mice, the authors demonstrate that PRAMEF12 is required to maintain germ cell homeostasis and promote their differentiation.
format	article
author	Zhengpin Wang Xiaojiang Xu Jian-Liang Li Cameron Palmer Dragan Maric Jurrien Dean
author_facet	Zhengpin Wang Xiaojiang Xu Jian-Liang Li Cameron Palmer Dragan Maric Jurrien Dean
author_sort	Zhengpin Wang
title	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice
title_short	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice
title_full	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice
title_fullStr	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice
title_full_unstemmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice
title_sort	sertoli cell-only phenotype and scrna-seq define pramef12 as a factor essential for spermatogenesis in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e2a52d907b7c4c48af38cd6b40f4377a
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Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice

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