BEARscc determines robustness of single-cell clusters using simulated technical replicates

Single cell messenger RNAseq allows the study of heterogeneity in tissue samples. Here the authors present BEARscc, a tool that uses RNA spike-in controls to simulate experiment-specific technical replicates to estimate the robustness of computational predictions of subpopulations of cells.

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Autores principales:	D. T. Severson, R. P. Owen, M. J. White, X. Lu, B. Schuster-Böckler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2a5876aba4b4caa92376abdac2b5548
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spelling	oai:doaj.org-article:e2a5876aba4b4caa92376abdac2b55482021-12-02T14:39:04ZBEARscc determines robustness of single-cell clusters using simulated technical replicates10.1038/s41467-018-03608-y2041-1723https://doaj.org/article/e2a5876aba4b4caa92376abdac2b55482018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03608-yhttps://doaj.org/toc/2041-1723Single cell messenger RNAseq allows the study of heterogeneity in tissue samples. Here the authors present BEARscc, a tool that uses RNA spike-in controls to simulate experiment-specific technical replicates to estimate the robustness of computational predictions of subpopulations of cells.D. T. SeversonR. P. OwenM. J. WhiteX. LuB. Schuster-BöcklerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q D. T. Severson R. P. Owen M. J. White X. Lu B. Schuster-Böckler BEARscc determines robustness of single-cell clusters using simulated technical replicates
description	Single cell messenger RNAseq allows the study of heterogeneity in tissue samples. Here the authors present BEARscc, a tool that uses RNA spike-in controls to simulate experiment-specific technical replicates to estimate the robustness of computational predictions of subpopulations of cells.
format	article
author	D. T. Severson R. P. Owen M. J. White X. Lu B. Schuster-Böckler
author_facet	D. T. Severson R. P. Owen M. J. White X. Lu B. Schuster-Böckler
author_sort	D. T. Severson
title	BEARscc determines robustness of single-cell clusters using simulated technical replicates
title_short	BEARscc determines robustness of single-cell clusters using simulated technical replicates
title_full	BEARscc determines robustness of single-cell clusters using simulated technical replicates
title_fullStr	BEARscc determines robustness of single-cell clusters using simulated technical replicates
title_full_unstemmed	BEARscc determines robustness of single-cell clusters using simulated technical replicates
title_sort	bearscc determines robustness of single-cell clusters using simulated technical replicates
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e2a5876aba4b4caa92376abdac2b5548
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BEARscc determines robustness of single-cell clusters using simulated technical replicates

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