Association Between Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Incidence of Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study
Lidan Chen,1,* Kebao Zhang,2,* Xue Li,2 Yang Wu,3 Qingwen Liu,4 Liting Xu,1 Liuyan Li,4 Haofei Hu5 1Shenzhen Nanshan Medical Group Headquarter, Shenzhen, Guangdong Province, 518000, People’s Republic of China; 2Department of Emergency, The Eighth Affiliated Hospital, Sun Yat-sen Univ...
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2021
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oai:doaj.org-article:e2acc0fbfa64431fa8be99b53d0f4ffe2021-12-02T19:36:19ZAssociation Between Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Incidence of Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study1178-7007https://doaj.org/article/e2acc0fbfa64431fa8be99b53d0f4ffe2021-11-01T00:00:00Zhttps://www.dovepress.com/association-between-aspartate-aminotransferase-to-alanine-aminotransfe-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Lidan Chen,1,* Kebao Zhang,2,* Xue Li,2 Yang Wu,3 Qingwen Liu,4 Liting Xu,1 Liuyan Li,4 Haofei Hu5 1Shenzhen Nanshan Medical Group Headquarter, Shenzhen, Guangdong Province, 518000, People’s Republic of China; 2Department of Emergency, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, Guangdong Province, People’s Republic of China; 3Department of Endocrinology, Shenzhen Second People’s Hospital, Shenzhen, 518000, Guangdong Province, People’s Republic of China; 4Shenzhen Second People’s Hospital, Shenzhen, 518000, Guangdong Province, People’s Republic of China; 5Department of Nephrology, Shenzhen Second People’s Hospital, Shenzhen, 518000, Guangdong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haofei HuDepartment of Nephrology, Shenzhen Second People’s Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518000, Guangdong Province, People’s Republic of ChinaTel +86-755-83366388Email huhaofei0319@126.comBackground: The study on the association between aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio and the risk of type 2 diabetes mellitus (T2DM) was limited. Therefore, we conducted a secondary analysis based on online data to explore whether there was an association between the AST/ALT ratio and incident T2DM among a large number of Japanese people.Methods: The study was a retrospective cohort study. We downloaded the NAGALA (NAfld in Gifu area) data from DATADRYAD website between 2004 and 2015. This present study included 15,291 participants. Cox proportional-hazards regression, generalized additive models and subgroup analyses were used to find out the association between the AST/ALT ratio and T2DM events.Results: The negative relationship was shown between AST/ALT ratio and incident T2DM (HR = 0.617, 95% CI: 0.405– 0.938) in our study. A non-linear relationship and saturation effect were found between them, and the inflection point was 0.882. It indicated that the AST/ALT ratio was negatively correlated with incident T2DM when the AST/ALT ratio was less than the inflection point (HR = 0.287, 95% CI: 0.126– 0.655, p = 0.0030). We found that exercise modified their relationship (P for interaction = 0.0024), and people who did not exercise associated strongly (HR = 0.464 95% CI: 0.290– 0.741).Conclusion: AST/ALT ratio was negatively associated with T2DM risk, and their relationship was non-linear and had a saturation effect. When the AST/ALT ratio was less than 0.882, they showed a significant negative correlation.Keywords: alanine aminotransferase, aspartate aminotransferase, type 2 diabetes mellitus, nonlinearityChen LZhang KLi XWu YLiu QXu LLi LHu HDove Medical Pressarticlealanine aminotransferaseaspartate aminotransferasetype 2 diabetes mellitusnonlinearitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4483-4495 (2021) |
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alanine aminotransferase aspartate aminotransferase type 2 diabetes mellitus nonlinearity Specialties of internal medicine RC581-951 |
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alanine aminotransferase aspartate aminotransferase type 2 diabetes mellitus nonlinearity Specialties of internal medicine RC581-951 Chen L Zhang K Li X Wu Y Liu Q Xu L Li L Hu H Association Between Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Incidence of Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study |
| description |
Lidan Chen,1,* Kebao Zhang,2,* Xue Li,2 Yang Wu,3 Qingwen Liu,4 Liting Xu,1 Liuyan Li,4 Haofei Hu5 1Shenzhen Nanshan Medical Group Headquarter, Shenzhen, Guangdong Province, 518000, People’s Republic of China; 2Department of Emergency, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, Guangdong Province, People’s Republic of China; 3Department of Endocrinology, Shenzhen Second People’s Hospital, Shenzhen, 518000, Guangdong Province, People’s Republic of China; 4Shenzhen Second People’s Hospital, Shenzhen, 518000, Guangdong Province, People’s Republic of China; 5Department of Nephrology, Shenzhen Second People’s Hospital, Shenzhen, 518000, Guangdong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haofei HuDepartment of Nephrology, Shenzhen Second People’s Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518000, Guangdong Province, People’s Republic of ChinaTel +86-755-83366388Email huhaofei0319@126.comBackground: The study on the association between aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio and the risk of type 2 diabetes mellitus (T2DM) was limited. Therefore, we conducted a secondary analysis based on online data to explore whether there was an association between the AST/ALT ratio and incident T2DM among a large number of Japanese people.Methods: The study was a retrospective cohort study. We downloaded the NAGALA (NAfld in Gifu area) data from DATADRYAD website between 2004 and 2015. This present study included 15,291 participants. Cox proportional-hazards regression, generalized additive models and subgroup analyses were used to find out the association between the AST/ALT ratio and T2DM events.Results: The negative relationship was shown between AST/ALT ratio and incident T2DM (HR = 0.617, 95% CI: 0.405– 0.938) in our study. A non-linear relationship and saturation effect were found between them, and the inflection point was 0.882. It indicated that the AST/ALT ratio was negatively correlated with incident T2DM when the AST/ALT ratio was less than the inflection point (HR = 0.287, 95% CI: 0.126– 0.655, p = 0.0030). We found that exercise modified their relationship (P for interaction = 0.0024), and people who did not exercise associated strongly (HR = 0.464 95% CI: 0.290– 0.741).Conclusion: AST/ALT ratio was negatively associated with T2DM risk, and their relationship was non-linear and had a saturation effect. When the AST/ALT ratio was less than 0.882, they showed a significant negative correlation.Keywords: alanine aminotransferase, aspartate aminotransferase, type 2 diabetes mellitus, nonlinearity |
| format |
article |
| author |
Chen L Zhang K Li X Wu Y Liu Q Xu L Li L Hu H |
| author_facet |
Chen L Zhang K Li X Wu Y Liu Q Xu L Li L Hu H |
| author_sort |
Chen L |
| title |
Association Between Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Incidence of Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study |
| title_short |
Association Between Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Incidence of Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study |
| title_full |
Association Between Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Incidence of Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study |
| title_fullStr |
Association Between Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Incidence of Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study |
| title_full_unstemmed |
Association Between Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Incidence of Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study |
| title_sort |
association between aspartate aminotransferase to alanine aminotransferase ratio and incidence of type 2 diabetes mellitus in the japanese population: a secondary analysis of a retrospective cohort study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/e2acc0fbfa64431fa8be99b53d0f4ffe |
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