Human NMD ensues independently of stable ribosome stalling

Nonsense-mediated mRNA decay (NMD) was thought to ensue when ribosomes fail to terminate translation properly. However, the authors observe similar ribosome occupancy at stop codons of NMD sensitive and insensitive mRNAs, showing that human NMD is not activated by stable ribosome stalling as previou...

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Autores principales:	Evangelos D. Karousis, Lukas-Adrian Gurzeler, Giuditta Annibaldis, René Dreos, Oliver Mühlemann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2ad888a263f4904912b1414bd2a56cf
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spelling	oai:doaj.org-article:e2ad888a263f4904912b1414bd2a56cf2021-12-02T18:01:13ZHuman NMD ensues independently of stable ribosome stalling10.1038/s41467-020-17974-z2041-1723https://doaj.org/article/e2ad888a263f4904912b1414bd2a56cf2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17974-zhttps://doaj.org/toc/2041-1723Nonsense-mediated mRNA decay (NMD) was thought to ensue when ribosomes fail to terminate translation properly. However, the authors observe similar ribosome occupancy at stop codons of NMD sensitive and insensitive mRNAs, showing that human NMD is not activated by stable ribosome stalling as previously suggested.Evangelos D. KarousisLukas-Adrian GurzelerGiuditta AnnibaldisRené DreosOliver MühlemannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evangelos D. Karousis Lukas-Adrian Gurzeler Giuditta Annibaldis René Dreos Oliver Mühlemann Human NMD ensues independently of stable ribosome stalling
description	Nonsense-mediated mRNA decay (NMD) was thought to ensue when ribosomes fail to terminate translation properly. However, the authors observe similar ribosome occupancy at stop codons of NMD sensitive and insensitive mRNAs, showing that human NMD is not activated by stable ribosome stalling as previously suggested.
format	article
author	Evangelos D. Karousis Lukas-Adrian Gurzeler Giuditta Annibaldis René Dreos Oliver Mühlemann
author_facet	Evangelos D. Karousis Lukas-Adrian Gurzeler Giuditta Annibaldis René Dreos Oliver Mühlemann
author_sort	Evangelos D. Karousis
title	Human NMD ensues independently of stable ribosome stalling
title_short	Human NMD ensues independently of stable ribosome stalling
title_full	Human NMD ensues independently of stable ribosome stalling
title_fullStr	Human NMD ensues independently of stable ribosome stalling
title_full_unstemmed	Human NMD ensues independently of stable ribosome stalling
title_sort	human nmd ensues independently of stable ribosome stalling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e2ad888a263f4904912b1414bd2a56cf
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Human NMD ensues independently of stable ribosome stalling

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