The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.

<h4>Objective</h4>To evaluate whether the risk of subsequent psoriasis and psoriatic arthritis development is increased in patients with uveitis.<h4>Methods</h4>In Taiwan's national health insurance research database, we identified 195,125 patients with new-onset uveitis...

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Autores principales:	Yu-Yen Chen, Hsin-Hua Chen, Tzu-Chen Lo, Pesus Chou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e2ae5ad164f6412da89e7fe88c5f0937
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spelling	oai:doaj.org-article:e2ae5ad164f6412da89e7fe88c5f09372021-12-02T20:18:50ZThe risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.1932-620310.1371/journal.pone.0255492https://doaj.org/article/e2ae5ad164f6412da89e7fe88c5f09372021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255492https://doaj.org/toc/1932-6203<h4>Objective</h4>To evaluate whether the risk of subsequent psoriasis and psoriatic arthritis development is increased in patients with uveitis.<h4>Methods</h4>In Taiwan's national health insurance research database, we identified 195,125 patients with new-onset uveitis between 2001 and 2013. We randomly selected 390,250 individuals without uveitis who were matched 2:1 to uveitis cases based on age, sex and year of enrolment. The characteristics of the two groups were compared. Using multivariate Cox regression, hazard ratios (HRs) for psoriasis or psoriatic arthritis corresponding to uveitis were computed after adjustment for age, sex, insurance cost and comorbidities. In subgroup analyses, separate HRs for mild psoriasis, severe psoriasis and psoriatic arthritis were calculated.<h4>Results</h4>The mean age of the study cohort was 50.2 ± 17.2 years. Hypertension, diabetes, hyperlipidaemia and obesity were more prevalent in the uveitis group (all p < 0.0001). The hazard of psoriasis or psoriatic arthritis development was significantly greater in the uveitis group than in the non-uveitis group (p < 0.0001); this increased risk persisted after adjustment for confounders [adjusted HR = 1.41; 95% confidence interval (CI), 1.33-1.48]. Adjusted HRs showed an increasing trend from mild psoriasis (1.35; 95% CI, 1.28-1.44) to severe psoriasis (1.59; 95% CI, 1.30-1.94) and psoriatic arthritis (1.97; 95% CI, 1.60-2.42).<h4>Conclusions</h4>This nationwide population-based cohort study revealed that patients with uveitis have an increased risk of subsequent psoriasis or psoriatic arthritis development.Yu-Yen ChenHsin-Hua ChenTzu-Chen LoPesus ChouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255492 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Yen Chen Hsin-Hua Chen Tzu-Chen Lo Pesus Chou The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.
description	<h4>Objective</h4>To evaluate whether the risk of subsequent psoriasis and psoriatic arthritis development is increased in patients with uveitis.<h4>Methods</h4>In Taiwan's national health insurance research database, we identified 195,125 patients with new-onset uveitis between 2001 and 2013. We randomly selected 390,250 individuals without uveitis who were matched 2:1 to uveitis cases based on age, sex and year of enrolment. The characteristics of the two groups were compared. Using multivariate Cox regression, hazard ratios (HRs) for psoriasis or psoriatic arthritis corresponding to uveitis were computed after adjustment for age, sex, insurance cost and comorbidities. In subgroup analyses, separate HRs for mild psoriasis, severe psoriasis and psoriatic arthritis were calculated.<h4>Results</h4>The mean age of the study cohort was 50.2 ± 17.2 years. Hypertension, diabetes, hyperlipidaemia and obesity were more prevalent in the uveitis group (all p < 0.0001). The hazard of psoriasis or psoriatic arthritis development was significantly greater in the uveitis group than in the non-uveitis group (p < 0.0001); this increased risk persisted after adjustment for confounders [adjusted HR = 1.41; 95% confidence interval (CI), 1.33-1.48]. Adjusted HRs showed an increasing trend from mild psoriasis (1.35; 95% CI, 1.28-1.44) to severe psoriasis (1.59; 95% CI, 1.30-1.94) and psoriatic arthritis (1.97; 95% CI, 1.60-2.42).<h4>Conclusions</h4>This nationwide population-based cohort study revealed that patients with uveitis have an increased risk of subsequent psoriasis or psoriatic arthritis development.
format	article
author	Yu-Yen Chen Hsin-Hua Chen Tzu-Chen Lo Pesus Chou
author_facet	Yu-Yen Chen Hsin-Hua Chen Tzu-Chen Lo Pesus Chou
author_sort	Yu-Yen Chen
title	The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.
title_short	The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.
title_full	The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.
title_fullStr	The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.
title_full_unstemmed	The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.
title_sort	risk of psoriasis in patients with uveitis: a nationwide population-based cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e2ae5ad164f6412da89e7fe88c5f0937
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The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study.

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