Modern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups

DCCT (Diabetes Control and Complications Trial) study established that intensified insulin therapy in multiple daily injections (MDI) or continuous insulin infusion (CSII) regimens substantially reduce both development and progression of complications in patients with type 1 diabetes mellitus (T1DM)...

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Autores principales:	Natalya Nikitichna Volevodz, Dmitriy Nikitich Laptev, Marina Vladimirovna Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	diabetes mellitus insulin analogues hypoglycemia Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/e2aff6d78bf2450a90afabf1468d9f15
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spelling	oai:doaj.org-article:e2aff6d78bf2450a90afabf1468d9f152021-11-14T09:00:17ZModern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups2072-03512072-037810.14341/2072-0351-3602https://doaj.org/article/e2aff6d78bf2450a90afabf1468d9f152013-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/3602https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378DCCT (Diabetes Control and Complications Trial) study established that intensified insulin therapy in multiple daily injections (MDI) or continuous insulin infusion (CSII) regimens substantially reduce both development and progression of complications in patients with type 1 diabetes mellitus (T1DM) as compared to conventional insulin therapy. Insulin analogues possess better pharmacokinetic and pharmacodynamic characteristics than unmodified human insulin agents. These characteristics are beneficial for management of diabetes mellitus, allowing better glycemic outcomes with lower incidence of hypoglycemia.Current review discusses specifics of therapy with glargine (Lantus?) and glulisine (Apidra?) insulin analogues. Authors analyzed available to date results from corresponding clinical trials in children, adolescents and adults. Pharmacoeconomic aspects and matters of dosage of glargine and glulisine are further addressed.Natalya Nikitichna VolevodzDmitriy Nikitich LaptevMarina Vladimirovna ShestakovaEndocrinology Research Centrearticlediabetes mellitusinsulin analogueshypoglycemiaNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 1, Pp 83-90 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus insulin analogues hypoglycemia Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus insulin analogues hypoglycemia Nutritional diseases. Deficiency diseases RC620-627 Natalya Nikitichna Volevodz Dmitriy Nikitich Laptev Marina Vladimirovna Shestakova Modern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups
description	DCCT (Diabetes Control and Complications Trial) study established that intensified insulin therapy in multiple daily injections (MDI) or continuous insulin infusion (CSII) regimens substantially reduce both development and progression of complications in patients with type 1 diabetes mellitus (T1DM) as compared to conventional insulin therapy. Insulin analogues possess better pharmacokinetic and pharmacodynamic characteristics than unmodified human insulin agents. These characteristics are beneficial for management of diabetes mellitus, allowing better glycemic outcomes with lower incidence of hypoglycemia.Current review discusses specifics of therapy with glargine (Lantus?) and glulisine (Apidra?) insulin analogues. Authors analyzed available to date results from corresponding clinical trials in children, adolescents and adults. Pharmacoeconomic aspects and matters of dosage of glargine and glulisine are further addressed.
format	article
author	Natalya Nikitichna Volevodz Dmitriy Nikitich Laptev Marina Vladimirovna Shestakova
author_facet	Natalya Nikitichna Volevodz Dmitriy Nikitich Laptev Marina Vladimirovna Shestakova
author_sort	Natalya Nikitichna Volevodz
title	Modern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups
title_short	Modern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups
title_full	Modern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups
title_fullStr	Modern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups
title_full_unstemmed	Modern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups
title_sort	modern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/e2aff6d78bf2450a90afabf1468d9f15
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Modern approach to basal-bolus therapy with glargine and glulisine insulin analoguesin various age groups

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