Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse.

<h4>Background</h4>Curcuma extract exerts a myorelaxant effect on the mouse intestine. In view of a possible use of curcuma extract in motor functional disorders of the gastrointestinal tract, a safety profile study has been carried out in the mouse.<h4>Methods</h4>Thirty mic...

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Autores principales:	Matteo Micucci, Rita Aldini, Monica Cevenini, Carolina Colliva, Silvia Spinozzi, Giulia Roda, Marco Montagnani, Cecilia Camborata, Luca Camarda, Alberto Chiarini, Giuseppe Mazzella, Roberta Budriesi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e2b662ba0cec4de8ae0ad7a4f38af312
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spelling	oai:doaj.org-article:e2b662ba0cec4de8ae0ad7a4f38af3122021-11-18T08:46:06ZCurcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse.1932-620310.1371/journal.pone.0080925https://doaj.org/article/e2b662ba0cec4de8ae0ad7a4f38af3122013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260512/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Curcuma extract exerts a myorelaxant effect on the mouse intestine. In view of a possible use of curcuma extract in motor functional disorders of the gastrointestinal tract, a safety profile study has been carried out in the mouse.<h4>Methods</h4>Thirty mice were used to study the in vitro effect of curcuma on gallbladder, bladder, aorta and trachea smooth muscular layers and hearth inotropic and chronotropic activity. The myorelaxant effect on the intestine was also thoroughly investigated. Moreover, curcuma extract (200 mg/Kg/day) was orally administered to twenty mice over 28 days and serum liver and lipids parameters were evaluated. Serum, bile and liver bile acids qualitative and quantitative composition was were also studied.<h4>Results</h4>In the intestine, curcuma extract appeared as a not competitive inhibitor through cholinergic, histaminergic and serotoninergic receptors and showed spasmolytic effect on K(+) induced contraction at the level of L type calcium channels. No side effect was observed on bladder, aorta, trachea and heart when we used a dose that is effective on the intestine. An increase in gallbladder tone and contraction was observed. Serum liver and lipids parameters were normal, while a slight increase in serum and liver bile acids concentration and a decrease in bile were observed.<h4>Conclusions</h4>Although these data are consistent with the safety of curcuma extract as far as its effect on the smooth muscular layers of different organs and on the heart, the mild cholestatic effect observed in absence of alteration of liver function tests must be further evaluated and the effective dose with minimal side effects considered.Matteo MicucciRita AldiniMonica CeveniniCarolina CollivaSilvia SpinozziGiulia RodaMarco MontagnaniCecilia CamborataLuca CamardaAlberto ChiariniGiuseppe MazzellaRoberta BudriesiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80925 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matteo Micucci Rita Aldini Monica Cevenini Carolina Colliva Silvia Spinozzi Giulia Roda Marco Montagnani Cecilia Camborata Luca Camarda Alberto Chiarini Giuseppe Mazzella Roberta Budriesi Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse.
description	<h4>Background</h4>Curcuma extract exerts a myorelaxant effect on the mouse intestine. In view of a possible use of curcuma extract in motor functional disorders of the gastrointestinal tract, a safety profile study has been carried out in the mouse.<h4>Methods</h4>Thirty mice were used to study the in vitro effect of curcuma on gallbladder, bladder, aorta and trachea smooth muscular layers and hearth inotropic and chronotropic activity. The myorelaxant effect on the intestine was also thoroughly investigated. Moreover, curcuma extract (200 mg/Kg/day) was orally administered to twenty mice over 28 days and serum liver and lipids parameters were evaluated. Serum, bile and liver bile acids qualitative and quantitative composition was were also studied.<h4>Results</h4>In the intestine, curcuma extract appeared as a not competitive inhibitor through cholinergic, histaminergic and serotoninergic receptors and showed spasmolytic effect on K(+) induced contraction at the level of L type calcium channels. No side effect was observed on bladder, aorta, trachea and heart when we used a dose that is effective on the intestine. An increase in gallbladder tone and contraction was observed. Serum liver and lipids parameters were normal, while a slight increase in serum and liver bile acids concentration and a decrease in bile were observed.<h4>Conclusions</h4>Although these data are consistent with the safety of curcuma extract as far as its effect on the smooth muscular layers of different organs and on the heart, the mild cholestatic effect observed in absence of alteration of liver function tests must be further evaluated and the effective dose with minimal side effects considered.
format	article
author	Matteo Micucci Rita Aldini Monica Cevenini Carolina Colliva Silvia Spinozzi Giulia Roda Marco Montagnani Cecilia Camborata Luca Camarda Alberto Chiarini Giuseppe Mazzella Roberta Budriesi
author_facet	Matteo Micucci Rita Aldini Monica Cevenini Carolina Colliva Silvia Spinozzi Giulia Roda Marco Montagnani Cecilia Camborata Luca Camarda Alberto Chiarini Giuseppe Mazzella Roberta Budriesi
author_sort	Matteo Micucci
title	Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse.
title_short	Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse.
title_full	Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse.
title_fullStr	Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse.
title_full_unstemmed	Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse.
title_sort	curcuma longa l. as a therapeutic agent in intestinal motility disorders. 2: safety profile in mouse.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e2b662ba0cec4de8ae0ad7a4f38af312
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Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse.

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