Scientific Opinion on the safety and efficacy of Optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows

Abstract The additive Optiphos® is a preparation of 6–phytase produced by a genetically modified strain of Pichia pastoris; it is presented in solid (G/CT) and liquid (L) forms ensuring 4000 OTU/g and 8000 OTU/mL, respectively. This product is intended for use in chickens and turkeys for fattening,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) and Panel on Genetically Modified Organisms (GMO)
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2011
Materias:	zootechnical additive digestibility enhancers 6‐phytase poultry pigs Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/e2b67f9f692547998543ef52c32c17cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e2b67f9f692547998543ef52c32c17cd
record_format	dspace
spelling	oai:doaj.org-article:e2b67f9f692547998543ef52c32c17cd2021-12-01T10:05:38ZScientific Opinion on the safety and efficacy of Optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows1831-473210.2903/j.efsa.2011.2414https://doaj.org/article/e2b67f9f692547998543ef52c32c17cd2011-11-01T00:00:00Zhttps://doi.org/10.2903/j.efsa.2011.2414https://doaj.org/toc/1831-4732Abstract The additive Optiphos® is a preparation of 6–phytase produced by a genetically modified strain of Pichia pastoris; it is presented in solid (G/CT) and liquid (L) forms ensuring 4000 OTU/g and 8000 OTU/mL, respectively. This product is intended for use in chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows. The final enzyme preparation contains no cultivable production organism or recombinant DNA. All major species tested tolerated the additive at 100–fold the maximum recommended dose. Consequently, the FEEDAP Panel concludes that the additive is safe at the maximum recommended dose for the target species. Based on the absence of treatment‐related adverse effects in two in vitro and one in vivo genotoxicity tests and in a subchronic oral toxicity study, it can be concluded that Optiphos® is of no concern regarding consumer safety when used as feed additive in food‐producing animals. The additive is not a skin/eye irritant or skin sensitiser. As an enzyme it is assumed that the additive has potential to be a respiratory sensitiser. The active substance of Optiphos® is a protein and as such will be degraded/inactivated during the passage through the digestive tract of animals. Therefore, no risks for the environment are expected and no further environmental risk assessment is required. Based on data on phosphorus utilisation, digestibility and bone mineralisation, the FEEDAP Panel concludes that the following doses are efficacious: (i) 125 OTU/kg in chickens for fattening and reared for laying, laying hens and sows, (ii) 250 OTU/kg in turkeys for fattening and reared for breeding, weaned piglets and pigs for fattening. The data from major poultry species can be extrapolated to other avian species for fattening and laying at a dose of 125 OTU/kg.EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) and Panel on Genetically Modified Organisms (GMO)Wileyarticlezootechnical additivedigestibility enhancers6‐phytasepoultrypigsNutrition. Foods and food supplyTX341-641Chemical technologyTP1-1185ENEFSA Journal, Vol 9, Iss 11, Pp n/a-n/a (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	zootechnical additive digestibility enhancers 6‐phytase poultry pigs Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185
spellingShingle	zootechnical additive digestibility enhancers 6‐phytase poultry pigs Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) and Panel on Genetically Modified Organisms (GMO) Scientific Opinion on the safety and efficacy of Optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows
description	Abstract The additive Optiphos® is a preparation of 6–phytase produced by a genetically modified strain of Pichia pastoris; it is presented in solid (G/CT) and liquid (L) forms ensuring 4000 OTU/g and 8000 OTU/mL, respectively. This product is intended for use in chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows. The final enzyme preparation contains no cultivable production organism or recombinant DNA. All major species tested tolerated the additive at 100–fold the maximum recommended dose. Consequently, the FEEDAP Panel concludes that the additive is safe at the maximum recommended dose for the target species. Based on the absence of treatment‐related adverse effects in two in vitro and one in vivo genotoxicity tests and in a subchronic oral toxicity study, it can be concluded that Optiphos® is of no concern regarding consumer safety when used as feed additive in food‐producing animals. The additive is not a skin/eye irritant or skin sensitiser. As an enzyme it is assumed that the additive has potential to be a respiratory sensitiser. The active substance of Optiphos® is a protein and as such will be degraded/inactivated during the passage through the digestive tract of animals. Therefore, no risks for the environment are expected and no further environmental risk assessment is required. Based on data on phosphorus utilisation, digestibility and bone mineralisation, the FEEDAP Panel concludes that the following doses are efficacious: (i) 125 OTU/kg in chickens for fattening and reared for laying, laying hens and sows, (ii) 250 OTU/kg in turkeys for fattening and reared for breeding, weaned piglets and pigs for fattening. The data from major poultry species can be extrapolated to other avian species for fattening and laying at a dose of 125 OTU/kg.
format	article
author	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) and Panel on Genetically Modified Organisms (GMO)
author_facet	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) and Panel on Genetically Modified Organisms (GMO)
author_sort	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) and Panel on Genetically Modified Organisms (GMO)
title	Scientific Opinion on the safety and efficacy of Optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows
title_short	Scientific Opinion on the safety and efficacy of Optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows
title_full	Scientific Opinion on the safety and efficacy of Optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows
title_fullStr	Scientific Opinion on the safety and efficacy of Optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows
title_full_unstemmed	Scientific Opinion on the safety and efficacy of Optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows
title_sort	scientific opinion on the safety and efficacy of optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows
publisher	Wiley
publishDate	2011
url	https://doaj.org/article/e2b67f9f692547998543ef52c32c17cd
work_keys_str_mv	AT efsapanelonadditivesandproductsorsubstancesusedinanimalfeedfeedapandpanelongeneticallymodifiedorganismsgmo scientificopiniononthesafetyandefficacyofoptiphos6phytaseasafeedadditiveforchickensandturkeysforfatteningchickensrearedforlayingturkeysrearedforbreedinglayinghensotherbirdsforfatteningandlayingweanedpigletspigsforfatteningandsows
_version_	1718405328732684288

Scientific Opinion on the safety and efficacy of Optiphos® (6‐phytase) as a feed additive for chickens and turkeys for fattening, chickens reared for laying, turkeys reared for breeding, laying hens, other birds for fattening and laying, weaned piglets, pigs for fattening and sows

Ejemplares similares