Augmentation with antidepressants in schizophrenia treatment: benefit or risk

Ye-Meng Mao, Ming-Dao Zhang Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, World Health Organization Collaborating Center for Research and Training in Mental Health, Shanghai, People’s Republic of China Abstract: We focused on the application o...

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Auteurs principaux:	Mao YM, Zhang MD
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2015
Sujets:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Accès en ligne:	https://doaj.org/article/e2bb9f8ea7e24f3095a4ebd48e7ec705
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id	oai:doaj.org-article:e2bb9f8ea7e24f3095a4ebd48e7ec705
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spelling	oai:doaj.org-article:e2bb9f8ea7e24f3095a4ebd48e7ec7052021-12-02T06:31:50ZAugmentation with antidepressants in schizophrenia treatment: benefit or risk1178-2021https://doaj.org/article/e2bb9f8ea7e24f3095a4ebd48e7ec7052015-03-01T00:00:00Zhttp://www.dovepress.com/augmentation-with-antidepressants-in-schizophrenia-treatment-benefit-o-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Ye-Meng Mao, Ming-Dao Zhang Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, World Health Organization Collaborating Center for Research and Training in Mental Health, Shanghai, People’s Republic of China Abstract: We focused on the application of antidepressants in schizophrenia treatment in this review. Augmentation of antidepressants with antipsychotics is a common clinical practice to treat resistant symptoms in schizophrenia, including depressive symptoms, negative symptoms, comorbid obsessive–compulsive symptoms, and other psychotic manifestations. However, recent systematic review of the clinical effects of antidepressants is lacking. In this review, we have selected and summarized current literature on the use of antidepressants in patients with schizophrenia; the patterns of use and effectiveness, as well as risks and drug–drug interactions of this clinical practice are discussed in detail, with particular emphasis on the treatment of depressive symptoms in schizophrenia. Keywords: depressive symptoms, drug-drug interaction, antipsychoticsMao YMZhang MDDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 701-713 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Mao YM Zhang MD Augmentation with antidepressants in schizophrenia treatment: benefit or risk
description	Ye-Meng Mao, Ming-Dao Zhang Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, World Health Organization Collaborating Center for Research and Training in Mental Health, Shanghai, People’s Republic of China Abstract: We focused on the application of antidepressants in schizophrenia treatment in this review. Augmentation of antidepressants with antipsychotics is a common clinical practice to treat resistant symptoms in schizophrenia, including depressive symptoms, negative symptoms, comorbid obsessive–compulsive symptoms, and other psychotic manifestations. However, recent systematic review of the clinical effects of antidepressants is lacking. In this review, we have selected and summarized current literature on the use of antidepressants in patients with schizophrenia; the patterns of use and effectiveness, as well as risks and drug–drug interactions of this clinical practice are discussed in detail, with particular emphasis on the treatment of depressive symptoms in schizophrenia. Keywords: depressive symptoms, drug-drug interaction, antipsychotics
format	article
author	Mao YM Zhang MD
author_facet	Mao YM Zhang MD
author_sort	Mao YM
title	Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_short	Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_full	Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_fullStr	Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_full_unstemmed	Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_sort	augmentation with antidepressants in schizophrenia treatment: benefit or risk
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e2bb9f8ea7e24f3095a4ebd48e7ec705
work_keys_str_mv	AT maoym augmentationwithantidepressantsinschizophreniatreatmentbenefitorrisk AT zhangmd augmentationwithantidepressantsinschizophreniatreatmentbenefitorrisk
_version_	1718399905905508352

Augmentation with antidepressants in schizophrenia treatment: benefit or risk

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