Augmentation with antidepressants in schizophrenia treatment: benefit or risk

Ye-Meng Mao, Ming-Dao Zhang Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, World Health Organization Collaborating Center for Research and Training in Mental Health, Shanghai, People’s Republic of China Abstract: We focused on the application o...

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Autores principales: Mao YM, Zhang MD
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Lenguaje:EN
Publicado: Dove Medical Press 2015
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Acceso en línea:https://doaj.org/article/e2bb9f8ea7e24f3095a4ebd48e7ec705
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spelling oai:doaj.org-article:e2bb9f8ea7e24f3095a4ebd48e7ec7052021-12-02T06:31:50ZAugmentation with antidepressants in schizophrenia treatment: benefit or risk1178-2021https://doaj.org/article/e2bb9f8ea7e24f3095a4ebd48e7ec7052015-03-01T00:00:00Zhttp://www.dovepress.com/augmentation-with-antidepressants-in-schizophrenia-treatment-benefit-o-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Ye-Meng Mao, Ming-Dao Zhang Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, World Health Organization Collaborating Center for Research and Training in Mental Health, Shanghai, People’s Republic of China Abstract: We focused on the application of antidepressants in schizophrenia treatment in this review. Augmentation of antidepressants with antipsychotics is a common clinical practice to treat resistant symptoms in schizophrenia, including depressive symptoms, negative symptoms, comorbid obsessive–compulsive symptoms, and other psychotic manifestations. However, recent systematic review of the clinical effects of antidepressants is lacking. In this review, we have selected and summarized current literature on the use of antidepressants in patients with schizophrenia; the patterns of use and effectiveness, as well as risks and drug–drug interactions of this clinical practice are discussed in detail, with particular emphasis on the treatment of depressive symptoms in schizophrenia. Keywords: depressive symptoms, drug-drug interaction, antipsychoticsMao YMZhang MDDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 701-713 (2015)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Mao YM
Zhang MD
Augmentation with antidepressants in schizophrenia treatment: benefit or risk
description Ye-Meng Mao, Ming-Dao Zhang Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, World Health Organization Collaborating Center for Research and Training in Mental Health, Shanghai, People’s Republic of China Abstract: We focused on the application of antidepressants in schizophrenia treatment in this review. Augmentation of antidepressants with antipsychotics is a common clinical practice to treat resistant symptoms in schizophrenia, including depressive symptoms, negative symptoms, comorbid obsessive–compulsive symptoms, and other psychotic manifestations. However, recent systematic review of the clinical effects of antidepressants is lacking. In this review, we have selected and summarized current literature on the use of antidepressants in patients with schizophrenia; the patterns of use and effectiveness, as well as risks and drug–drug interactions of this clinical practice are discussed in detail, with particular emphasis on the treatment of depressive symptoms in schizophrenia. Keywords: depressive symptoms, drug-drug interaction, antipsychotics
format article
author Mao YM
Zhang MD
author_facet Mao YM
Zhang MD
author_sort Mao YM
title Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_short Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_full Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_fullStr Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_full_unstemmed Augmentation with antidepressants in schizophrenia treatment: benefit or risk
title_sort augmentation with antidepressants in schizophrenia treatment: benefit or risk
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/e2bb9f8ea7e24f3095a4ebd48e7ec705
work_keys_str_mv AT maoym augmentationwithantidepressantsinschizophreniatreatmentbenefitorrisk
AT zhangmd augmentationwithantidepressantsinschizophreniatreatmentbenefitorrisk
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