Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults

The locus coeruleus is critical for selective information processing by modulating the brain’s connectivity configuration. Increasingly, studies have suggested that LC controls sensory inputs at the sensory gating stage. Furthermore, accumulating evidence has shown that young children and older adul...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Inuk Song, Joshua Neal, Tae-Ho Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	locus coeruleus distractibility neurodevelopment functional connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e2bc1b950ac1433d914c8980fa9d50f1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e2bc1b950ac1433d914c8980fa9d50f1
record_format	dspace
spelling	oai:doaj.org-article:e2bc1b950ac1433d914c8980fa9d50f12021-11-25T16:58:18ZAge-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults10.3390/brainsci111114852076-3425https://doaj.org/article/e2bc1b950ac1433d914c8980fa9d50f12021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1485https://doaj.org/toc/2076-3425The locus coeruleus is critical for selective information processing by modulating the brain’s connectivity configuration. Increasingly, studies have suggested that LC controls sensory inputs at the sensory gating stage. Furthermore, accumulating evidence has shown that young children and older adults are more prone to distraction and filter out irrelevant information less efficiently, possibly due to the unoptimized LC connectivity. However, the LC connectivity pattern across the life span is not fully examined yet, hampering our ability to understand the relationship between LC development and the distractibility. In this study, we examined the intrinsic network connectivity of the LC using a public fMRI dataset with wide-range age samples. Based on LC-seed functional connectivity maps, we examined the age-related variation in the LC connectivity with a quadratic model. The analyses revealed two connectivity patterns explicitly. The sensory-related brain regions showed a positive quadratic age effect (u-shape), and the frontal regions for the cognitive control showed a negative quadratic age effect (inverted u-shape). Our results imply that such age-related distractibility is possibly due to the impaired sensory gating by the LC and the insufficient top-down controls by the frontal regions. We discuss the underlying neural mechanisms and limitations of our study.Inuk SongJoshua NealTae-Ho LeeMDPI AGarticlelocus coeruleusdistractibilityneurodevelopmentfunctional connectivityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1485, p 1485 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	locus coeruleus distractibility neurodevelopment functional connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	locus coeruleus distractibility neurodevelopment functional connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Inuk Song Joshua Neal Tae-Ho Lee Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults
description	The locus coeruleus is critical for selective information processing by modulating the brain’s connectivity configuration. Increasingly, studies have suggested that LC controls sensory inputs at the sensory gating stage. Furthermore, accumulating evidence has shown that young children and older adults are more prone to distraction and filter out irrelevant information less efficiently, possibly due to the unoptimized LC connectivity. However, the LC connectivity pattern across the life span is not fully examined yet, hampering our ability to understand the relationship between LC development and the distractibility. In this study, we examined the intrinsic network connectivity of the LC using a public fMRI dataset with wide-range age samples. Based on LC-seed functional connectivity maps, we examined the age-related variation in the LC connectivity with a quadratic model. The analyses revealed two connectivity patterns explicitly. The sensory-related brain regions showed a positive quadratic age effect (u-shape), and the frontal regions for the cognitive control showed a negative quadratic age effect (inverted u-shape). Our results imply that such age-related distractibility is possibly due to the impaired sensory gating by the LC and the insufficient top-down controls by the frontal regions. We discuss the underlying neural mechanisms and limitations of our study.
format	article
author	Inuk Song Joshua Neal Tae-Ho Lee
author_facet	Inuk Song Joshua Neal Tae-Ho Lee
author_sort	Inuk Song
title	Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults
title_short	Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults
title_full	Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults
title_fullStr	Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults
title_full_unstemmed	Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults
title_sort	age-related intrinsic functional connectivity changes of locus coeruleus from childhood to older adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e2bc1b950ac1433d914c8980fa9d50f1
work_keys_str_mv	AT inuksong agerelatedintrinsicfunctionalconnectivitychangesoflocuscoeruleusfromchildhoodtoolderadults AT joshuaneal agerelatedintrinsicfunctionalconnectivitychangesoflocuscoeruleusfromchildhoodtoolderadults AT taeholee agerelatedintrinsicfunctionalconnectivitychangesoflocuscoeruleusfromchildhoodtoolderadults
_version_	1718412868796284928

Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults

Ejemplares similares