Generation of functional ciliated cholangiocytes from human pluripotent stem cells

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Generation of functional ciliated cholangiocytes from human pluripotent stem cells

Current protocols to generate cholangiocytes from human pluripotent cells produce immature cells. Here the authors identify retinoic acid, BMP, cAMP and Rho kinase pathways as regulators of cholangiocyte maturation, and generate ciliated cholangiocytes expressing high levels of CFTR that form ductal...

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Auteurs principaux:	Mina Ogawa, Jia-Xin Jiang, Sunny Xia, Donghe Yang, Avrilynn Ding, Onofrio Laselva, Marcela Hernandez, Changyi Cui, Yuichiro Higuchi, Hiroshi Suemizu, Craig Dorrell, Markus Grompe, Christine E. Bear, Shinichiro Ogawa
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e2c37e554f8c4d829b4039f62abf625f
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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