Clinicopathological study of gall bladder cancer and its relationship with gall stones

Introduction: Gall bladder cancer is the most common cancer of the biliary tree and one of the highly malignant tumors with poor prognosis. Although its incidence is low in west, it is common in our part of the world. There are very few studies regarding gall bladder cancer in Nepal. The incidence...

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Autores principales:	R Poudel, SK Singh, S Basnet, H Devkota, SK Adhikari
Formato:	article
Lenguaje:	EN
Publicado:	Society of Surgeons of Nepal 2016
Materias:	Gall bladder cancer Gallstones Surgery RD1-811
Acceso en línea:	https://doaj.org/article/e2c4f58b53d943e5a8b443eddc581cfe
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spelling	oai:doaj.org-article:e2c4f58b53d943e5a8b443eddc581cfe2021-12-05T19:16:33ZClinicopathological study of gall bladder cancer and its relationship with gall stones10.3126/jssn.v18i3.153081815-39842392-4772https://doaj.org/article/e2c4f58b53d943e5a8b443eddc581cfe2016-07-01T00:00:00Zhttps://www.nepjol.info/index.php/JSSN/article/view/15308https://doaj.org/toc/1815-3984https://doaj.org/toc/2392-4772 Introduction: Gall bladder cancer is the most common cancer of the biliary tree and one of the highly malignant tumors with poor prognosis. Although its incidence is low in west, it is common in our part of the world. There are very few studies regarding gall bladder cancer in Nepal. The incidence of gallstones in patients with gall bladder cancer is high. The aim of the study was to evaluate the clinicopathological aspect of the disease in patients with gallbladder cancer and to Asses the incidence of gallstones in patients with gall bladder cancer. Material and Methods: This was a retrospective study carried out in GI Surgery unit of National Academy of Medical Science, Bir Hospital, Kathmandu, Nepal. All patients diagnosed as gallbladder carcinomas during 12 years period from 2002 to 2014 were included in this study. Their clinical characteristics, laboratory data, tumor histopathology reports were obtained and analyzed using SPSS17. Results: Total of 47 patients who met inclusion criteria were included in the study. Male to Female ratio was 1:1.8. Age ranged from 32 to 72 years with mean age of 54. Most common presenting symptom was Pain abdomen (93.6%) followed by weight loss (51.1%) and Jaundice (46.8%). Most common finding on examination was Icterus (42.6%) followed by palpable gall bladder (34%) and Hepatomegaly (29.8%). Gall Stones were seen in 37 (72.3%) patients. Most common histopathology was Adenocarcinoma (93.6%). Conclusion: Most of the patient with gall bladder cancer remained asymptomatic until late. Pain abdomen was most common presenting symptom and icterus was most common findings. There was strong association between gall bladder cancer and gallstones. There should be high index of suspicion if patient with gallstones has constant pain in right hypochondrium and has jaundice. R PoudelSK SinghS BasnetH DevkotaSK AdhikariSociety of Surgeons of NepalarticleGall bladder cancerGallstonesSurgeryRD1-811ENJournal of Society of Surgeons of Nepal, Vol 18, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gall bladder cancer Gallstones Surgery RD1-811
spellingShingle	Gall bladder cancer Gallstones Surgery RD1-811 R Poudel SK Singh S Basnet H Devkota SK Adhikari Clinicopathological study of gall bladder cancer and its relationship with gall stones
description	Introduction: Gall bladder cancer is the most common cancer of the biliary tree and one of the highly malignant tumors with poor prognosis. Although its incidence is low in west, it is common in our part of the world. There are very few studies regarding gall bladder cancer in Nepal. The incidence of gallstones in patients with gall bladder cancer is high. The aim of the study was to evaluate the clinicopathological aspect of the disease in patients with gallbladder cancer and to Asses the incidence of gallstones in patients with gall bladder cancer. Material and Methods: This was a retrospective study carried out in GI Surgery unit of National Academy of Medical Science, Bir Hospital, Kathmandu, Nepal. All patients diagnosed as gallbladder carcinomas during 12 years period from 2002 to 2014 were included in this study. Their clinical characteristics, laboratory data, tumor histopathology reports were obtained and analyzed using SPSS17. Results: Total of 47 patients who met inclusion criteria were included in the study. Male to Female ratio was 1:1.8. Age ranged from 32 to 72 years with mean age of 54. Most common presenting symptom was Pain abdomen (93.6%) followed by weight loss (51.1%) and Jaundice (46.8%). Most common finding on examination was Icterus (42.6%) followed by palpable gall bladder (34%) and Hepatomegaly (29.8%). Gall Stones were seen in 37 (72.3%) patients. Most common histopathology was Adenocarcinoma (93.6%). Conclusion: Most of the patient with gall bladder cancer remained asymptomatic until late. Pain abdomen was most common presenting symptom and icterus was most common findings. There was strong association between gall bladder cancer and gallstones. There should be high index of suspicion if patient with gallstones has constant pain in right hypochondrium and has jaundice.
format	article
author	R Poudel SK Singh S Basnet H Devkota SK Adhikari
author_facet	R Poudel SK Singh S Basnet H Devkota SK Adhikari
author_sort	R Poudel
title	Clinicopathological study of gall bladder cancer and its relationship with gall stones
title_short	Clinicopathological study of gall bladder cancer and its relationship with gall stones
title_full	Clinicopathological study of gall bladder cancer and its relationship with gall stones
title_fullStr	Clinicopathological study of gall bladder cancer and its relationship with gall stones
title_full_unstemmed	Clinicopathological study of gall bladder cancer and its relationship with gall stones
title_sort	clinicopathological study of gall bladder cancer and its relationship with gall stones
publisher	Society of Surgeons of Nepal
publishDate	2016
url	https://doaj.org/article/e2c4f58b53d943e5a8b443eddc581cfe
work_keys_str_mv	AT rpoudel clinicopathologicalstudyofgallbladdercanceranditsrelationshipwithgallstones AT sksingh clinicopathologicalstudyofgallbladdercanceranditsrelationshipwithgallstones AT sbasnet clinicopathologicalstudyofgallbladdercanceranditsrelationshipwithgallstones AT hdevkota clinicopathologicalstudyofgallbladdercanceranditsrelationshipwithgallstones AT skadhikari clinicopathologicalstudyofgallbladdercanceranditsrelationshipwithgallstones
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Clinicopathological study of gall bladder cancer and its relationship with gall stones

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