Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie

Hippo signaling leads to the phosphorylation of the key transcriptional effector, Yap/Yki, although how Yap/Yki stability is regulated has remained unclear. Here, Sun et al. identify HAUSP/Usp7 as a conserved and clinically relevant regulator of the Hippo pathway that increases Yap/Yki stability.

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Autores principales:	Xiaohan Sun, Yan Ding, Meixiao Zhan, Yan Li, Dongqing Gao, Guiping Wang, Yang Gao, Yong Li, Shian Wu, Ligong Lu, Qingxin Liu, Zizhang Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2c58fc3b2ea4374beb8dbfa56e71a7e
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spelling	oai:doaj.org-article:e2c58fc3b2ea4374beb8dbfa56e71a7e2021-12-02T15:35:27ZUsp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie10.1038/s41467-019-08334-72041-1723https://doaj.org/article/e2c58fc3b2ea4374beb8dbfa56e71a7e2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08334-7https://doaj.org/toc/2041-1723Hippo signaling leads to the phosphorylation of the key transcriptional effector, Yap/Yki, although how Yap/Yki stability is regulated has remained unclear. Here, Sun et al. identify HAUSP/Usp7 as a conserved and clinically relevant regulator of the Hippo pathway that increases Yap/Yki stability.Xiaohan SunYan DingMeixiao ZhanYan LiDongqing GaoGuiping WangYang GaoYong LiShian WuLigong LuQingxin LiuZizhang ZhouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaohan Sun Yan Ding Meixiao Zhan Yan Li Dongqing Gao Guiping Wang Yang Gao Yong Li Shian Wu Ligong Lu Qingxin Liu Zizhang Zhou Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
description	Hippo signaling leads to the phosphorylation of the key transcriptional effector, Yap/Yki, although how Yap/Yki stability is regulated has remained unclear. Here, Sun et al. identify HAUSP/Usp7 as a conserved and clinically relevant regulator of the Hippo pathway that increases Yap/Yki stability.
format	article
author	Xiaohan Sun Yan Ding Meixiao Zhan Yan Li Dongqing Gao Guiping Wang Yang Gao Yong Li Shian Wu Ligong Lu Qingxin Liu Zizhang Zhou
author_facet	Xiaohan Sun Yan Ding Meixiao Zhan Yan Li Dongqing Gao Guiping Wang Yang Gao Yong Li Shian Wu Ligong Lu Qingxin Liu Zizhang Zhou
author_sort	Xiaohan Sun
title	Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
title_short	Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
title_full	Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
title_fullStr	Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
title_full_unstemmed	Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
title_sort	usp7 regulates hippo pathway through deubiquitinating the transcriptional coactivator yorkie
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e2c58fc3b2ea4374beb8dbfa56e71a7e
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Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie

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