Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie

Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie

Hippo signaling leads to the phosphorylation of the key transcriptional effector, Yap/Yki, although how Yap/Yki stability is regulated has remained unclear. Here, Sun et al. identify HAUSP/Usp7 as a conserved and clinically relevant regulator of the Hippo pathway that increases Yap/Yki stability.

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Detalles Bibliográficos
Autores principales: Xiaohan Sun, Yan Ding, Meixiao Zhan, Yan Li, Dongqing Gao, Guiping Wang, Yang Gao, Yong Li, Shian Wu, Ligong Lu, Qingxin Liu, Zizhang Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e2c58fc3b2ea4374beb8dbfa56e71a7e
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