Synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents

A new series of 2-[3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-4-pyrazolyl]-3-aryl-1,3-thiazolan-4-one 5(a-i) have been designed, synthesized and evaluated for their in vitro antibacterial activity against Gram positive bacteria viz. Bacillus subtilis (ATCC 6633), Staphylococcus...

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Autores principales:	Nagaraj Adki, Neelofer Rana, Ramesh Naik Palthya
Formato:	article
Lenguaje:	EN
Publicado:	Growing Science 2022
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e2c5a088390d43479aed56cb052b83b9
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spelling	oai:doaj.org-article:e2c5a088390d43479aed56cb052b83b92021-11-12T12:52:43ZSynthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents1927-72961927-730X10.5267/j.ccl.2021.8.001https://doaj.org/article/e2c5a088390d43479aed56cb052b83b92022-01-01T00:00:00Zhttp://www.growingscience.com/ccl/Vol11/ccl_2021_28.pdfhttps://doaj.org/toc/1927-7296https://doaj.org/toc/1927-730X A new series of 2-[3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-4-pyrazolyl]-3-aryl-1,3-thiazolan-4-one 5(a-i) have been designed, synthesized and evaluated for their in vitro antibacterial activity against Gram positive bacteria viz. Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 6538p), Micrococcus luteus (IFC 12708) and Gram negative bacteria viz. Proteus vulgaris (ATCC 3851), Salmonella typhimurium (ATCC 14028), Escherichia coli (ATCC 25922) the antifungal activity against Candida albicans (ATCC 10231), Aspergillus fumigatus (HIC 6094), Trichophyton rubrum (IFO 9185), Trichophyton mentagrophytes (IFO 40996). Antibacterial evaluation indicates that compounds containing 4-methoxyphenyl 5c, 4-fluorophenyl 5d and 2,5-difluorophenyl 5h groups on thiazolidinone ring showed significant activity equal to that of standard drug. The antifungal evaluation shows that compound 5c is highly active against A. fumigatus, compound 5d and 5h were also active against C. albicans and A. fumigatus.Nagaraj AdkiNeelofer RanaRamesh Naik PalthyaGrowing SciencearticleChemistryQD1-999ENCurrent Chemistry Letters, Vol 11, Iss 1, Pp 139-146 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Nagaraj Adki Neelofer Rana Ramesh Naik Palthya Synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents
description	A new series of 2-[3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-4-pyrazolyl]-3-aryl-1,3-thiazolan-4-one 5(a-i) have been designed, synthesized and evaluated for their in vitro antibacterial activity against Gram positive bacteria viz. Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 6538p), Micrococcus luteus (IFC 12708) and Gram negative bacteria viz. Proteus vulgaris (ATCC 3851), Salmonella typhimurium (ATCC 14028), Escherichia coli (ATCC 25922) the antifungal activity against Candida albicans (ATCC 10231), Aspergillus fumigatus (HIC 6094), Trichophyton rubrum (IFO 9185), Trichophyton mentagrophytes (IFO 40996). Antibacterial evaluation indicates that compounds containing 4-methoxyphenyl 5c, 4-fluorophenyl 5d and 2,5-difluorophenyl 5h groups on thiazolidinone ring showed significant activity equal to that of standard drug. The antifungal evaluation shows that compound 5c is highly active against A. fumigatus, compound 5d and 5h were also active against C. albicans and A. fumigatus.
format	article
author	Nagaraj Adki Neelofer Rana Ramesh Naik Palthya
author_facet	Nagaraj Adki Neelofer Rana Ramesh Naik Palthya
author_sort	Nagaraj Adki
title	Synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents
title_short	Synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents
title_full	Synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents
title_fullStr	Synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents
title_full_unstemmed	Synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents
title_sort	synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents
publisher	Growing Science
publishDate	2022
url	https://doaj.org/article/e2c5a088390d43479aed56cb052b83b9
work_keys_str_mv	AT nagarajadki synthesisandbiologicalevaluationofpyrazoleanalogueslinkedwith123triazoleand4thiazolidinoneasantimicrobialagents AT neeloferrana synthesisandbiologicalevaluationofpyrazoleanalogueslinkedwith123triazoleand4thiazolidinoneasantimicrobialagents AT rameshnaikpalthya synthesisandbiologicalevaluationofpyrazoleanalogueslinkedwith123triazoleand4thiazolidinoneasantimicrobialagents
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Synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents

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