Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation

Huijin Lau,1 Suzana Shahar,1 Mazlyfarina Mohamad,2 Nor Fadilah Rajab,3 Hanis Mastura Yahya,1 Normah Che Din,4 Hamzaini Abdul Hamid5 1Center for Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Diagnostic Imaging and Radiotherapy Program...

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Autores principales:	Lau H, Shahar S, Mohamad M, Rajab NF, Yahya HM, Che Din N, Abdul Hamid H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Brain activation fMRI HDL-C Vitamin B6 Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e2ca762ade444959a0f8dc017125d319
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spelling	oai:doaj.org-article:e2ca762ade444959a0f8dc017125d3192021-12-02T01:03:26ZRelationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation1178-1998https://doaj.org/article/e2ca762ade444959a0f8dc017125d3192018-12-01T00:00:00Zhttps://www.dovepress.com/relationships-between-dietary-nutrients-intake-and-lipid-levels-with-f-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Huijin Lau,1 Suzana Shahar,1 Mazlyfarina Mohamad,2 Nor Fadilah Rajab,3 Hanis Mastura Yahya,1 Normah Che Din,4 Hamzaini Abdul Hamid5 1Center for Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Diagnostic Imaging and Radiotherapy Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 3Biomedical Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 4Health Psychology Program, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 5Department of Radiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia Background: Dorsolateral prefrontal cortex (DLPFC) is a key node in the cognitive control network that supports working memory. DLPFC dysfunction is related to cognitive impairment. It has been suggested that dietary components and high-density lipoprotein cholesterol (HDL-C) play a vital role in brain health and cognitive function.Purpose: This study aimed to investigate the relationships between dietary nutrient intake and lipid levels with functional MRI (fMRI) brain activation in DLPFC among older adults with mild cognitive impairment. Participants and methods: A total of 15 community-dwelling older adults with mild cognitive impairment, aged ≥60 years, participated in this cross-sectional study at selected senior citizen clubs in Klang Valley, Malaysia. The 7-day recall Diet History Questionnaire was used to assess participants’ dietary nutrient intake. Fasting blood samples were also collected for lipid profile assessment. All participants performed N-back (0- and 1-back) working memory tasks during fMRI scanning. DLPFC (Brodmann’s areas 9 and 46, and inferior, middle, and superior frontal gyrus) was identified as a region of interest for analysis.Results: Positive associations were observed between dietary intake of energy, protein, cholesterol, vitamins B6 and B12, potassium, iron, phosphorus, magnesium, and HDL-C with DLPFC activation (P<0.05). Multivariate analysis showed that vitamin B6 intake, β=0.505, t (14)=3.29, P=0.023, and Digit Symbol score, β=0.413, t (14)=2.89, P=0.045; R2=0.748, were positively related to DLPFC activation.Conclusion: Increased vitamin B6 intake and cognitive processing speed were related to greater activation in the DLPFC region, which was responsible for working memory, executive function, attention, planning, and decision making. Further studies are needed to elucidate the mechanisms underlying the association.Keywords: brain activation, fMRI, HDL-C, vitamin B6Lau HShahar SMohamad MRajab NFYahya HMChe Din NAbdul Hamid HDove Medical PressarticleBrain activationfMRIHDL-CVitamin B6GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 43-51 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brain activation fMRI HDL-C Vitamin B6 Geriatrics RC952-954.6
spellingShingle	Brain activation fMRI HDL-C Vitamin B6 Geriatrics RC952-954.6 Lau H Shahar S Mohamad M Rajab NF Yahya HM Che Din N Abdul Hamid H Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation
description	Huijin Lau,1 Suzana Shahar,1 Mazlyfarina Mohamad,2 Nor Fadilah Rajab,3 Hanis Mastura Yahya,1 Normah Che Din,4 Hamzaini Abdul Hamid5 1Center for Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Diagnostic Imaging and Radiotherapy Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 3Biomedical Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 4Health Psychology Program, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 5Department of Radiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia Background: Dorsolateral prefrontal cortex (DLPFC) is a key node in the cognitive control network that supports working memory. DLPFC dysfunction is related to cognitive impairment. It has been suggested that dietary components and high-density lipoprotein cholesterol (HDL-C) play a vital role in brain health and cognitive function.Purpose: This study aimed to investigate the relationships between dietary nutrient intake and lipid levels with functional MRI (fMRI) brain activation in DLPFC among older adults with mild cognitive impairment. Participants and methods: A total of 15 community-dwelling older adults with mild cognitive impairment, aged ≥60 years, participated in this cross-sectional study at selected senior citizen clubs in Klang Valley, Malaysia. The 7-day recall Diet History Questionnaire was used to assess participants’ dietary nutrient intake. Fasting blood samples were also collected for lipid profile assessment. All participants performed N-back (0- and 1-back) working memory tasks during fMRI scanning. DLPFC (Brodmann’s areas 9 and 46, and inferior, middle, and superior frontal gyrus) was identified as a region of interest for analysis.Results: Positive associations were observed between dietary intake of energy, protein, cholesterol, vitamins B6 and B12, potassium, iron, phosphorus, magnesium, and HDL-C with DLPFC activation (P<0.05). Multivariate analysis showed that vitamin B6 intake, β=0.505, t (14)=3.29, P=0.023, and Digit Symbol score, β=0.413, t (14)=2.89, P=0.045; R2=0.748, were positively related to DLPFC activation.Conclusion: Increased vitamin B6 intake and cognitive processing speed were related to greater activation in the DLPFC region, which was responsible for working memory, executive function, attention, planning, and decision making. Further studies are needed to elucidate the mechanisms underlying the association.Keywords: brain activation, fMRI, HDL-C, vitamin B6
format	article
author	Lau H Shahar S Mohamad M Rajab NF Yahya HM Che Din N Abdul Hamid H
author_facet	Lau H Shahar S Mohamad M Rajab NF Yahya HM Che Din N Abdul Hamid H
author_sort	Lau H
title	Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation
title_short	Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation
title_full	Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation
title_fullStr	Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation
title_full_unstemmed	Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation
title_sort	relationships between dietary nutrients intake and lipid levels with functional mri dorsolateral prefrontal cortex activation
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/e2ca762ade444959a0f8dc017125d319
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Relationships between dietary nutrients intake and lipid levels with functional MRI dorsolateral prefrontal cortex activation

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