Mechanical stress determines the configuration of TGFβ activation in articular cartilage

Mechanical stress determines the configuration of TGFβ activation in articular cartilage

The functional relationship between subchondral bone and articular cartilage is unclear. Here, the authors show that transforming growth factor-beta propagates the mechanical impact of subchondral bone on articular cartilage through αV integrin–talin mechanical transduction system in chondrocytes....

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Bibliographic Details
Main Authors: Gehua Zhen, Qiaoyue Guo, Yusheng Li, Chuanlong Wu, Shouan Zhu, Ruomei Wang, X. Edward Guo, Byoung Choul Kim, Jessie Huang, Yizhong Hu, Yang Dan, Mei Wan, Taekjip Ha, Steven An, Xu Cao
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/e2cbba79acc140fcb2a2e1bea0be1268
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Summary:The functional relationship between subchondral bone and articular cartilage is unclear. Here, the authors show that transforming growth factor-beta propagates the mechanical impact of subchondral bone on articular cartilage through αV integrin–talin mechanical transduction system in chondrocytes.

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