Mechanical stress determines the configuration of TGFβ activation in articular cartilage

The functional relationship between subchondral bone and articular cartilage is unclear. Here, the authors show that transforming growth factor-beta propagates the mechanical impact of subchondral bone on articular cartilage through αV integrin–talin mechanical transduction system in chondrocytes....

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Autores principales:	Gehua Zhen, Qiaoyue Guo, Yusheng Li, Chuanlong Wu, Shouan Zhu, Ruomei Wang, X. Edward Guo, Byoung Choul Kim, Jessie Huang, Yizhong Hu, Yang Dan, Mei Wan, Taekjip Ha, Steven An, Xu Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2cbba79acc140fcb2a2e1bea0be1268
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spelling	oai:doaj.org-article:e2cbba79acc140fcb2a2e1bea0be12682021-12-02T13:17:40ZMechanical stress determines the configuration of TGFβ activation in articular cartilage10.1038/s41467-021-21948-02041-1723https://doaj.org/article/e2cbba79acc140fcb2a2e1bea0be12682021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21948-0https://doaj.org/toc/2041-1723The functional relationship between subchondral bone and articular cartilage is unclear. Here, the authors show that transforming growth factor-beta propagates the mechanical impact of subchondral bone on articular cartilage through αV integrin–talin mechanical transduction system in chondrocytes.Gehua ZhenQiaoyue GuoYusheng LiChuanlong WuShouan ZhuRuomei WangX. Edward GuoByoung Choul KimJessie HuangYizhong HuYang DanMei WanTaekjip HaSteven AnXu CaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gehua Zhen Qiaoyue Guo Yusheng Li Chuanlong Wu Shouan Zhu Ruomei Wang X. Edward Guo Byoung Choul Kim Jessie Huang Yizhong Hu Yang Dan Mei Wan Taekjip Ha Steven An Xu Cao Mechanical stress determines the configuration of TGFβ activation in articular cartilage
description	The functional relationship between subchondral bone and articular cartilage is unclear. Here, the authors show that transforming growth factor-beta propagates the mechanical impact of subchondral bone on articular cartilage through αV integrin–talin mechanical transduction system in chondrocytes.
format	article
author	Gehua Zhen Qiaoyue Guo Yusheng Li Chuanlong Wu Shouan Zhu Ruomei Wang X. Edward Guo Byoung Choul Kim Jessie Huang Yizhong Hu Yang Dan Mei Wan Taekjip Ha Steven An Xu Cao
author_facet	Gehua Zhen Qiaoyue Guo Yusheng Li Chuanlong Wu Shouan Zhu Ruomei Wang X. Edward Guo Byoung Choul Kim Jessie Huang Yizhong Hu Yang Dan Mei Wan Taekjip Ha Steven An Xu Cao
author_sort	Gehua Zhen
title	Mechanical stress determines the configuration of TGFβ activation in articular cartilage
title_short	Mechanical stress determines the configuration of TGFβ activation in articular cartilage
title_full	Mechanical stress determines the configuration of TGFβ activation in articular cartilage
title_fullStr	Mechanical stress determines the configuration of TGFβ activation in articular cartilage
title_full_unstemmed	Mechanical stress determines the configuration of TGFβ activation in articular cartilage
title_sort	mechanical stress determines the configuration of tgfβ activation in articular cartilage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e2cbba79acc140fcb2a2e1bea0be1268
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Mechanical stress determines the configuration of TGFβ activation in articular cartilage

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