Molecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.

<h4>Background</h4>The process of metastasis involves a series of steps and interactions between the tumor embolus and the microenvironment. Key alterations in adhesion molecules are known to dictate progression from the invasive to malignant phenotype followed by colonization at a dista...

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Autores principales:	Salomé S Pinho, Celso A Reis, Fátima Gärtner, Mary L Alpaugh
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e2d2d6b6c41d4bba9fabdde073eab870
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spelling	oai:doaj.org-article:e2d2d6b6c41d4bba9fabdde073eab8702021-11-25T06:21:00ZMolecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.1932-620310.1371/journal.pone.0006636https://doaj.org/article/e2d2d6b6c41d4bba9fabdde073eab8702009-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19675678/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The process of metastasis involves a series of steps and interactions between the tumor embolus and the microenvironment. Key alterations in adhesion molecules are known to dictate progression from the invasive to malignant phenotype followed by colonization at a distant site. The invasive phenotype results from the loss of expression of the E-cadherin adhesion molecule, whereas the malignant phenotype is associated with an increased expression of the carbohydrate ligand-binding epitopes, (e.g. Sialyl Lewis (x/a)) that bind endothelial E-selectin of the lymphatics and vasculature.<h4>Methodology</h4>Our study analyzed the expression of two adhesion molecules, E-cadherin and Sialyl Lewis x (sLe(x)), in both a canine mammary carcinoma and human inflammatory breast cancer (IBC) model, using double labelled immunofluorescence staining.<h4>Results</h4>Our results demonstrate that canine mammary carcinoma and human IBC exhibit an inversely correlated cellular expression of E-cadherin and sLe(x) within the same tumor embolus.<h4>Conclusions</h4>Our results in these two comparative models (canine and human) suggest the existence of a biologically coordinated mechanism of E-cadherin and sLe(x) expression (i.e. molecular plasticity) essential for tumor establishment and metastatic progression.Salomé S PinhoCelso A ReisFátima GärtnerMary L AlpaughPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 8, p e6636 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Salomé S Pinho Celso A Reis Fátima Gärtner Mary L Alpaugh Molecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.
description	<h4>Background</h4>The process of metastasis involves a series of steps and interactions between the tumor embolus and the microenvironment. Key alterations in adhesion molecules are known to dictate progression from the invasive to malignant phenotype followed by colonization at a distant site. The invasive phenotype results from the loss of expression of the E-cadherin adhesion molecule, whereas the malignant phenotype is associated with an increased expression of the carbohydrate ligand-binding epitopes, (e.g. Sialyl Lewis (x/a)) that bind endothelial E-selectin of the lymphatics and vasculature.<h4>Methodology</h4>Our study analyzed the expression of two adhesion molecules, E-cadherin and Sialyl Lewis x (sLe(x)), in both a canine mammary carcinoma and human inflammatory breast cancer (IBC) model, using double labelled immunofluorescence staining.<h4>Results</h4>Our results demonstrate that canine mammary carcinoma and human IBC exhibit an inversely correlated cellular expression of E-cadherin and sLe(x) within the same tumor embolus.<h4>Conclusions</h4>Our results in these two comparative models (canine and human) suggest the existence of a biologically coordinated mechanism of E-cadherin and sLe(x) expression (i.e. molecular plasticity) essential for tumor establishment and metastatic progression.
format	article
author	Salomé S Pinho Celso A Reis Fátima Gärtner Mary L Alpaugh
author_facet	Salomé S Pinho Celso A Reis Fátima Gärtner Mary L Alpaugh
author_sort	Salomé S Pinho
title	Molecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.
title_short	Molecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.
title_full	Molecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.
title_fullStr	Molecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.
title_full_unstemmed	Molecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.
title_sort	molecular plasticity of e-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/e2d2d6b6c41d4bba9fabdde073eab870
work_keys_str_mv	AT salomespinho molecularplasticityofecadherinandsialyllewisxexpressionintwocomparativemodelsofmammarytumorigenesis AT celsoareis molecularplasticityofecadherinandsialyllewisxexpressionintwocomparativemodelsofmammarytumorigenesis AT fatimagartner molecularplasticityofecadherinandsialyllewisxexpressionintwocomparativemodelsofmammarytumorigenesis AT marylalpaugh molecularplasticityofecadherinandsialyllewisxexpressionintwocomparativemodelsofmammarytumorigenesis
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Molecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis.

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