A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection

A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection

Here, the authors report the engineering, structural and biological characterization of synthetic nanobodies (sybodies) that display potent therapeutic activity against SARS-CoV-2 infection in animal models via targeting the virus receptor-binding domain.

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Autores principales: Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H. GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A. J. Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S. Richard, Hervé Raoul, Jiaming Lan, Markus A. Seeger, Yao Cong, Barry Rockx, Gary Wong, Yuhai Bi, Dimitri Lavillette, Dianfan Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/e2d2ef9db7c042d5ae0d4a35e2484adb
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spelling oai:doaj.org-article:e2d2ef9db7c042d5ae0d4a35e2484adb2021-12-02T16:30:15ZA synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection10.1038/s41467-021-24905-z2041-1723https://doaj.org/article/e2d2ef9db7c042d5ae0d4a35e2484adb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24905-zhttps://doaj.org/toc/2041-1723Here, the authors report the engineering, structural and biological characterization of synthetic nanobodies (sybodies) that display potent therapeutic activity against SARS-CoV-2 infection in animal models via targeting the virus receptor-binding domain.Tingting LiHongmin CaiHebang YaoBingjie ZhouNing ZhangMartje Fentener van VlissingenThijs KuikenWenyu HanCorine H. GeurtsvanKesselYuhuan GongYapei ZhaoQuan ShenWenming QinXiao-Xu TianChao PengYanling LaiYanxing WangCedric A. J. HutterShu-Ming KuoJuan BaoCaixuan LiuYifan WangAudrey S. RichardHervé RaoulJiaming LanMarkus A. SeegerYao CongBarry RockxGary WongYuhai BiDimitri LavilletteDianfan LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tingting Li
Hongmin Cai
Hebang Yao
Bingjie Zhou
Ning Zhang
Martje Fentener van Vlissingen
Thijs Kuiken
Wenyu Han
Corine H. GeurtsvanKessel
Yuhuan Gong
Yapei Zhao
Quan Shen
Wenming Qin
Xiao-Xu Tian
Chao Peng
Yanling Lai
Yanxing Wang
Cedric A. J. Hutter
Shu-Ming Kuo
Juan Bao
Caixuan Liu
Yifan Wang
Audrey S. Richard
Hervé Raoul
Jiaming Lan
Markus A. Seeger
Yao Cong
Barry Rockx
Gary Wong
Yuhai Bi
Dimitri Lavillette
Dianfan Li
A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
description Here, the authors report the engineering, structural and biological characterization of synthetic nanobodies (sybodies) that display potent therapeutic activity against SARS-CoV-2 infection in animal models via targeting the virus receptor-binding domain.
format article
author Tingting Li
Hongmin Cai
Hebang Yao
Bingjie Zhou
Ning Zhang
Martje Fentener van Vlissingen
Thijs Kuiken
Wenyu Han
Corine H. GeurtsvanKessel
Yuhuan Gong
Yapei Zhao
Quan Shen
Wenming Qin
Xiao-Xu Tian
Chao Peng
Yanling Lai
Yanxing Wang
Cedric A. J. Hutter
Shu-Ming Kuo
Juan Bao
Caixuan Liu
Yifan Wang
Audrey S. Richard
Hervé Raoul
Jiaming Lan
Markus A. Seeger
Yao Cong
Barry Rockx
Gary Wong
Yuhai Bi
Dimitri Lavillette
Dianfan Li
author_facet Tingting Li
Hongmin Cai
Hebang Yao
Bingjie Zhou
Ning Zhang
Martje Fentener van Vlissingen
Thijs Kuiken
Wenyu Han
Corine H. GeurtsvanKessel
Yuhuan Gong
Yapei Zhao
Quan Shen
Wenming Qin
Xiao-Xu Tian
Chao Peng
Yanling Lai
Yanxing Wang
Cedric A. J. Hutter
Shu-Ming Kuo
Juan Bao
Caixuan Liu
Yifan Wang
Audrey S. Richard
Hervé Raoul
Jiaming Lan
Markus A. Seeger
Yao Cong
Barry Rockx
Gary Wong
Yuhai Bi
Dimitri Lavillette
Dianfan Li
author_sort Tingting Li
title A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
title_short A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
title_full A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
title_fullStr A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
title_full_unstemmed A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
title_sort synthetic nanobody targeting rbd protects hamsters from sars-cov-2 infection
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e2d2ef9db7c042d5ae0d4a35e2484adb
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